Global Patent Index - EP 1098889 A1

EP 1098889 A1 2001-05-16 - SUBSTITUTED PIPERAZONES AND THEIR THERAPEUTIC USES

Title (en)

SUBSTITUTED PIPERAZONES AND THEIR THERAPEUTIC USES

Title (de)

SUBSTITUIERTE PIPERAZINONEN UND DEREN VERWENDUNGEN ALS HEILMITTEL

Title (fr)

PIPERAZINONES SUBSTITUEES ET LEURS APPLICATIONS EN THERAPEUTIQUE

Publication

EP 1098889 A1 (FR)

Application

EP 99929498 A

Priority

  • FR 9901751 W
  • FR 9809169 A

Abstract (en)

[origin: FR2781221A1] 1-(4-amidino phenyl)-4-substituted piperazinone derivatives (I) are new. The new compounds are of formula (I): R1 = H, 1-4C alkyl, or phenyl 1-4C alkyl; the carbonyl group = may be in position 2 or 3 of the piperazine ring R2 = H, OH, or a group protecting the amidino group; R3 = -NH-CO-R6, or -NH-SO2-R7; R4 and R5 = H, 1-5C alkyl or, together with the N atom, form piperidinyl or morpholinyl; R6 = 1-4C alkoxy, 3-7C cycloalkoxy, benzyloxy, methoxyphenyl, dimethoxyphenyl, benzodioxolyl, or benzodioxanyl; R7 = 1-5C alkyl (optionally substituted by one or more halogens, OH or CF3), 3-12C mono- bi-or tri-cyclic cycloalkyl, 6 - 14C mono- bi-or tri-cyclic cycloalkyl aryl, pyridyl, thienyl, quinolyl, benzodioxanyl, benzodioxolyl, isoxazolyl, phenyl 1-4C alkyl, naphthyl 1-4C alkyl, or a condensed bicyclic group of formula (A); n = 1, 2, or 3, aryl and heteroaryl groups within R7 may be substituted by halogens, 1-4C alkyl, CF3, 1-4C alkylthio, alkoxy, alkylsulfonyl, NO2, di 1-4C alkyl amino, phenyl, naphthyl, thienyl, furyl, pyridyl, -COOR, -CH2-COOR, -O-CH2-COOR; R = 1-4C alkyl:

IPC 1-7 (main, further and additional classification)

C07D 241/08; A61K 31/495

IPC 8 full level (invention and additional information)

A61K 31/495 (2006.01); A61P 7/02 (2006.01); A61P 43/00 (2006.01); C07D 241/08 (2006.01)

CPC (invention and additional information)

C07D 241/08 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

See references of WO 0004001A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2781221 A1 20000121; FR 2781221 B1 20001013; AU 4629399 A 20000207; AU 751981 B2 20020905; BR 9912153 A 20010410; CA 2337880 A1 20000127; CN 1173957 C 20041103; CN 1314895 A 20010926; EA 003430 B1 20030424; EA 200100152 A1 20010625; EP 1098889 A1 20010516; JP 2002520402 A 20020709; NZ 509167 A 20030829; US 6335337 B1 20020101; WO 0004001 A1 20000127

INPADOC legal status


2008-04-16 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20071016

2003-10-22 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030908

2001-05-16 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010102

2001-05-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-16 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI