EP 1098989 A1 20010516 - IMPROVED PROCESS FOR CLAVULANIC ACID PRODUCTION
Title (en)
IMPROVED PROCESS FOR CLAVULANIC ACID PRODUCTION
Title (de)
VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CLAVULANSÄURE
Title (fr)
PROCEDE AMELIORE DE PRODUCTION D'ACIDE CLAVULANIQUE
Publication
Application
Priority
- PT 9900012 W 19990719
- PT 10218198 A 19980720
Abstract (en)
[origin: WO0005397A1] The present invention concerns a process for clavulanic acid production by aerobic fermentation using selected and/or culture collection strains of Streptomyces clavuligerus, or mutants thereof. Accordingly, the culture is carried out with continuous or semicontinuous feeding of one or more organic nitrogen complex sources, preferably soybean meal, so as to control the protein concentration in the filtered broth within certain limits during the time course of the fermentation. The described conditions led to significant improvements in the clavulanic acid fermentation.
IPC 1-7
IPC 8 full level
C12P 17/18 (2006.01)
CPC (source: EP)
C12P 17/18 (2013.01)
Citation (search report)
See references of WO 0005397A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0005397 A1 20000203; AU 4808899 A 20000214; CA 2337074 A1 20000203; CN 1310766 A 20010829; EP 1098989 A1 20010516; MX PA01000653 A 20020408; PT 102181 A 20000131; TR 200100167 T2 20010521
DOCDB simple family (application)
PT 9900012 W 19990719; AU 4808899 A 19990719; CA 2337074 A 19990719; CN 99808891 A 19990719; EP 99931644 A 19990719; MX PA01000653 A 19990719; PT 10218198 A 19980720; TR 200100167 T 19990719