Global Patent Index - EP 1098989 A1

EP 1098989 A1 2001-05-16 - IMPROVED PROCESS FOR CLAVULANIC ACID PRODUCTION

Title (en)

IMPROVED PROCESS FOR CLAVULANIC ACID PRODUCTION

Title (de)

VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CLAVULANSÄURE

Title (fr)

PROCEDE AMELIORE DE PRODUCTION D'ACIDE CLAVULANIQUE

Publication

EP 1098989 A1 (EN)

Application

EP 99931644 A

Priority

  • PT 9900012 W
  • PT 10218198 A

Abstract (en)

[origin: WO0005397A1] The present invention concerns a process for clavulanic acid production by aerobic fermentation using selected and/or culture collection strains of Streptomyces clavuligerus, or mutants thereof. Accordingly, the culture is carried out with continuous or semicontinuous feeding of one or more organic nitrogen complex sources, preferably soybean meal, so as to control the protein concentration in the filtered broth within certain limits during the time course of the fermentation. The described conditions led to significant improvements in the clavulanic acid fermentation.

IPC 1-7 (main, further and additional classification)

C12P 17/18

IPC 8 full level (invention and additional information)

C12P 17/18 (2006.01)

CPC (invention and additional information)

C12P 17/18 (2013.01)

Citation (search report)

See references of WO 0005397A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0005397 A1 20000203; AU 4808899 A 20000214; CA 2337074 A1 20000203; CN 1310766 A 20010829; EP 1098989 A1 20010516; MX PA01000653 A 20020408; PT 102181 A 20000131; TR 200100167 T2 20010521

INPADOC legal status


2003-08-13 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20030201

2001-05-16 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010102

2001-05-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-16 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20010102;LT PAYMENT 20010102;LV PAYMENT 20010102;MK PAYMENT 20010102;RO PAYMENT 20010102;SI PAYMENT 20010102