Global Patent Index - EP 1100500 A1

EP 1100500 A1 2001-05-23 - THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION

Title (en)

THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION

Title (de)

VERWENDUNG VON KLEINEN CD-4 BINDENDEN MOLEKÜLEN ZUR HEMMUNG DER HIV-INFEKTION

Title (fr)

UTILISATION DE PETITES MOLECULES A LIAISON CD-4 POUR INHIBER L'INFECTION PAR LE VIH

Publication

EP 1100500 A1 (EN)

Application

EP 99938767 A

Priority

  • US 9916358 W
  • US 9356298 P
  • US 12810599 P

Abstract (en)

[origin: WO0004903A1] A method of inhibiting HIV-1 infection is provided that comprises administering to a subject an effective amount of an active compound having a molecular weight of between 200 daltons and 650 daltons. At a concentration of not more than 100 mu M, compounds useful in the practice of the invention inhibit greater than 50 % of the binding of gp120 to CD4. Preferred compounds are further characterized in that they inhibit less than 10 % of the binding of human CD4-expressing, CD4-transfected COS cells to Raji cells.

IPC 1-7 (main, further and additional classification)

A61K 31/41

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01); A61K 31/41 (2006.01); A61K 31/4196 (2006.01); A61K 31/427 (2006.01); A61K 31/429 (2006.01); A61K 31/4439 (2006.01)

CPC (invention and additional information)

A61K 31/4439 (2013.01); A61K 31/00 (2013.01); A61K 31/41 (2013.01); A61K 31/4196 (2013.01); A61K 31/427 (2013.01); A61K 31/429 (2013.01)

Citation (search report)

See references of WO 0004903A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0004903 A1 20000203; CA 2338329 A1 20000203; EP 1100500 A1 20010523

INPADOC legal status


2002-09-25 [18W] WITHDRAWN

- Date of withdrawal: 20020802

2001-05-23 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010221

2001-05-23 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE