EP 1100544 A1 20010523 - ALLOGENEIC CELLULAR IMMUNOGENS USEFUL AS CANCER VACCINES
Title (en)
ALLOGENEIC CELLULAR IMMUNOGENS USEFUL AS CANCER VACCINES
Title (de)
ALLOGENE, ZELLULÄRE IMMUNOGENE, DIE ALS KREBSIMPFSTOFF EINSETZBAR SIND
Title (fr)
IMMUNOGENES CELLULAIRES ALLOGENIQUES UTILES COMME VACCINS CONTRE LE CANCER
Publication
Application
Priority
- US 9915594 W 19990708
- US 9396598 P 19980724
Abstract (en)
[origin: WO0004927A1] A cellular immunogen is provided for immunizing a host against the effects of the product of a target proto-oncogene, where the overexpression of the target proto-oncogene is associated with a malignancy. The cellular immunogen comprises allogeneic (with respect to the host) cells which have been transfected with at least one transgene construct comprising a transgene cognate to the target proto-oncogene and a strong promoter to drive the expression of the transgene in the transfected cells. The transgene encodes a gene product which induces host immunoreactivity to host self-determinants of the product of the target proto-oncogene gene. The transgene may comprise, for example, wild-type or mutant retroviral oncogene DNA cognate to the target proto-oncogene; or wild-type or mutant proto-oncogene DNA of a species different from the host species. The cellular immunogen may be prepared from allogeneic donor cells, e.g. skin fibroblasts, which are stably or transiently transfected with the transgene construct containing the cognate transgene. The donor cells transfected with the cognate transgene constructs are then inserted into the body of the host to obtain expression of the cognate transgene in the host.
IPC 1-7
A61K 48/00; A01N 63/00; C12N 15/63; C12N 15/85; C12N 15/86; C07H 21/04
IPC 8 full level
A61K 39/00 (2006.01)
CPC (source: EP US)
A61K 39/0011 (2013.01 - EP US); A61K 39/001106 (2018.08 - EP US); A61K 39/001152 (2018.08 - EP US); A61K 39/001164 (2018.08 - EP US); A61K 2039/5156 (2013.01 - EP); A61K 2039/53 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0004927 A1 20000203; AU 4981999 A 20000214; EP 1100544 A1 20010523; EP 1100544 A4 20030115
DOCDB simple family (application)
US 9915594 W 19990708; AU 4981999 A 19990708; EP 99933855 A 19990708