Global Patent Index - EP 1100544 A1

EP 1100544 A1 2001-05-23 - ALLOGENEIC CELLULAR IMMUNOGENS USEFUL AS CANCER VACCINES

Title (en)

ALLOGENEIC CELLULAR IMMUNOGENS USEFUL AS CANCER VACCINES

Title (de)

ALLOGENE, ZELLULÄRE IMMUNOGENE, DIE ALS KREBSIMPFSTOFF EINSETZBAR SIND

Title (fr)

IMMUNOGENES CELLULAIRES ALLOGENIQUES UTILES COMME VACCINS CONTRE LE CANCER

Publication

EP 1100544 A1 (EN)

Application

EP 99933855 A

Priority

  • US 9915594 W
  • US 9396598 P

Abstract (en)

[origin: WO0004927A1] A cellular immunogen is provided for immunizing a host against the effects of the product of a target proto-oncogene, where the overexpression of the target proto-oncogene is associated with a malignancy. The cellular immunogen comprises allogeneic (with respect to the host) cells which have been transfected with at least one transgene construct comprising a transgene cognate to the target proto-oncogene and a strong promoter to drive the expression of the transgene in the transfected cells. The transgene encodes a gene product which induces host immunoreactivity to host self-determinants of the product of the target proto-oncogene gene. The transgene may comprise, for example, wild-type or mutant retroviral oncogene DNA cognate to the target proto-oncogene; or wild-type or mutant proto-oncogene DNA of a species different from the host species. The cellular immunogen may be prepared from allogeneic donor cells, e.g. skin fibroblasts, which are stably or transiently transfected with the transgene construct containing the cognate transgene. The donor cells transfected with the cognate transgene constructs are then inserted into the body of the host to obtain expression of the cognate transgene in the host.

IPC 1-7 (main, further and additional classification)

A61K 48/00; A01N 63/00; C07H 21/04; C12N 15/63; C12N 15/85; C12N 15/86

IPC 8 full level (invention and additional information)

A61K 39/00 (2006.01)

CPC (invention and additional information)

A61K 39/0011 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/53 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0004927 A1 20000203; AU 4981999 A 20000214; EP 1100544 A1 20010523; EP 1100544 A4 20030115

INPADOC legal status


2004-09-22 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040302

2003-12-10 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031022

2003-01-15 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20021129

2003-01-15 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-23 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010223

2001-05-23 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-23 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI