EP 1100779 A1 20010523 - SUBSTITUTED INDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS
Title (en)
SUBSTITUTED INDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS
Title (de)
SUBSTITUIERTE INDOLINONE, IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
Title (fr)
INDOLINONES SUBSTITUEES, LEUR PRODUCTION ET LEUR UTILISATION COMME MEDICAMENTS
Publication
Application
Priority
- DE 19824922 A 19980604
- EP 9903692 W 19990528
Abstract (en)
[origin: WO9962882A1] The invention relates to substituted indolinones of general formula (I) in which R1 to R5 and X are defined as in Claim No. 1, to the isomers thereof, and to their salts, especially to the physiologically compatible salts thereof, which exhibit valuable pharmacological characteristics, especially an inhibiting effect on different kinases and cyclin/CDK complexes, and on the proliferation of different tumor cells. The invention also relates to medicaments containing these compounds, to their use, and to a method for the production thereof.
IPC 1-7
C07D 209/34; C07D 209/30; C07D 401/12; C07D 403/12; C07D 417/12; A61K 31/40; A61K 31/44; A61K 31/47; A61K 31/415; A61K 31/425; A61K 31/55
IPC 8 full level
A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/404 (2006.01); A61K 31/4178 (2006.01); A61K 31/427 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 401/12 (2006.01); A61K 31/541 (2006.01); A61K 31/55 (2006.01); A61P 35/00 (2006.01); C07D 209/30 (2006.01); C07D 209/34 (2006.01); C07D 209/44 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 513/04 (2006.01)
CPC (source: EP)
A61P 35/00 (2018.01); C07D 209/30 (2013.01); C07D 209/34 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9962882 A1 19991209; AU 4370799 A 19991220; AU 764782 B2 20030828; BG 104938 A 20010629; BR 9910898 A 20010213; CA 2328291 A1 19991209; CN 1303374 A 20010711; CO 5050294 A1 20010627; DE 19824922 A1 19991209; EA 003514 B1 20030626; EA 200100001 A1 20010827; EE 200000723 A 20020415; EP 1100779 A1 20010523; HR P20000831 A2 20011231; HU P0102210 A2 20011128; HU P0102210 A3 20021228; ID 27035 A 20010222; IL 138702 A0 20011031; JP 2002516906 A 20020611; KR 20010043973 A 20010525; NO 20006138 D0 20001201; NO 20006138 L 20010201; PL 344467 A1 20011105; SK 18222000 A3 20010806; TR 200003515 T2 20010621; YU 73900 A 20030430; ZA 200005435 B 20020107
DOCDB simple family (application)
EP 9903692 W 19990528; AU 4370799 A 19990528; BG 10493800 A 20001113; BR 9910898 A 19990528; CA 2328291 A 19990528; CN 99806884 A 19990528; CO 99035396 A 19990604; DE 19824922 A 19980604; EA 200100001 A 19990528; EE P200000723 A 19990528; EP 99926454 A 19990528; HR P20000831 A 20001201; HU P0102210 A 19990528; ID 20002523 A 19990528; IL 13870299 A 19990528; JP 2000552094 A 19990528; KR 20007013597 A 20001201; NO 20006138 A 20001201; PL 34446799 A 19990528; SK 18222000 A 19990528; TR 200003515 T 19990528; YU 73900 A 19990528; ZA 200005435 A 20001005