Global Patent Index - EP 1100807 A1

EP 1100807 A1 2001-05-23 - STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS

Title (en)

STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS

Title (de)

STEREOISOMERE VON CPG OLIGONUKLEOTIDEN UND VERWANDTE VERFAHREN

Title (fr)

STEREO-ISOMERES D'OLIGONUCLEOTIDES DE TYPE CpG ET PROCEDES CONNEXES

Publication

EP 1100807 A1 (EN)

Application

EP 99938843 A

Priority

  • US 9917100 W
  • US 9437098 P

Abstract (en)

[origin: WO0006588A1] The interactions of nucleic acids with proteins can be selective for the R stereoisomer, the S stereoisomer, or can be stereoindependent. The present invention demonstrates that the S stereoisomer of CpG containing DNA is active in mediating the immune stimulatory effects of CpG DNA. The invention provides methods of use of a pure stereoisomer or of DNA enriched for this form for clinical applications for CpG DNA, such as vaccine adjuvants, immune activators for the prevention or treatment of retroviral, viral, parasitic or fungal diseases, or cancer immunotherapy, immunotherapy of allergic and asthmatic diseases, etc. The invention also provides methods of use for R stereoisomer DNA to oppose the immune stimulatory effects of CpG DNA. Such R stereoisomers are useful in the treatment of diseases such as Sepsis syndrome, intestinal inflammatory diseases, psoriasis, gingivitis, systemic lupus erythematosus and other autoimmune diseases.

IPC 1-7 (main, further and additional classification)

C07H 21/00; A61K 31/70; C12N 15/11

IPC 8 full level (invention and additional information)

A61K 31/711 (2006.01); A61P 11/06 (2006.01); A61P 17/00 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01); A61P 37/08 (2006.01); C07H 21/00 (2006.01); C12N 15/117 (2010.01)

CPC (invention and additional information)

C12N 15/117 (2013.01); C07H 21/00 (2013.01); C12N 2310/312 (2013.01)

Citation (search report)

See references of WO 0006588A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0006588 A1 20000210; WO 0006588 B1 20000406; AU 5323899 A 20000221; AU 764532 B2 20030821; CA 2333854 A1 20000210; EP 1100807 A1 20010523; JP 2002521489 A 20020716

INPADOC legal status


2004-06-09 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20031202

2003-01-22 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20021209

2001-05-23 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010227

2001-05-23 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-23 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI