Global Patent Index - EP 1100826 A4

EP 1100826 A4 20020807 - ISOFORMS OF HUMAN CALCIUM SENSING RECEPTOR

Title (en)

ISOFORMS OF HUMAN CALCIUM SENSING RECEPTOR

Title (de)

ISOFORMEN DES MENSCHLICHEN DURCH KALZIUM BEEINFLUSSBAREN REZEPTORS

Title (fr)

ISOFORMES DE RECEPTEUR DE CALCIUM HUMAIN

Publication

EP 1100826 A4 20020807 (EN)

Application

EP 99937584 A 19990728

Priority

  • US 9917116 W 19990728
  • US 9470298 P 19980730

Abstract (en)

[origin: WO0006601A1] The present invention relates to isoforms of a human calcium sensing receptor, and to the genes encoding these isoforms. The invention further relates to methods of screening for agonists or antagonists of the isoforms, particularly with respect to calcium receptor activity, to diagnostic uses of these isoforms and to therapeutic uses of the agonists or antagonists. The invention also relates to gene therapy using the genes encoding the receptor isoforms or molecules capable of down-regulating receptor activity, such as antisense sequences.

IPC 1-7

C07K 14/705; C07K 16/28; C12N 5/10; C12N 15/12

IPC 8 full level

G01N 33/50 (2006.01); A61K 31/7088 (2006.01); A61K 35/74 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 3/14 (2006.01); A61P 5/18 (2006.01); A61P 9/12 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 3/14 (2017.12); A61P 5/18 (2017.12); A61P 9/12 (2017.12); A61P 19/10 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/705 (2013.01); C07K 14/723 (2013.01)

Citation (search report)

  • [DX] ODA Y. ET AL: "A novel alternative splicing of the calcium receptor correlates with keratinocyte differentiation", FASEB JOURNAL, vol. 11, no. 9, 1997, pages A925, XP001080428
  • [XY] FREICHEL M ET AL: "EXPRESSION OF A CALCIUM-SENSING RECEPTOR IN A HUMAN MEDULLARY THYROID CARCINOMA CELL LINE AND ITS CONTRIBUTION TO CALCITONIN SECRETION", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 137, no. 9, September 1996 (1996-09-01), pages 3842 - 3848, XP002925084, ISSN: 0013-7227
  • [Y] JOURNOT L ET AL: "THE PACAP RECEPTOR: GENERATION BY ALTERNATIVE SPLICING OF FUNCTIONAL DIVERSITY AMONG G PROTEIN- COUPLED RECEPTORS IN NERVE CELLS", SEMINARS IN CELL BIOLOGY, SAUNDERS SCIENTIFIC PUBLICATIONS, PHILADELPHIA,, US, vol. 5, no. 4, August 1994 (1994-08-01), pages 263 - 272, XP001008535, ISSN: 1043-4675
  • [A] PEARCE S.H.S. ET AL: "Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism", JOURNAL FOR CLINICAL INVESTIGATION, vol. 96, 1995, pages 2683 - 2692, XP001079436
  • See references of WO 0006601A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0006601 A1 20000210; AU 5238999 A 20000221; AU 767010 B2 20031030; CA 2336543 A1 20000210; EP 1100826 A1 20010523; EP 1100826 A4 20020807; JP 2002521052 A 20020716

DOCDB simple family (application)

US 9917116 W 19990728; AU 5238999 A 19990728; CA 2336543 A 19990728; EP 99937584 A 19990728; JP 2000562397 A 19990728