EP 1100887 A1 20010523 - GROWTH DIFFERENTIATION FACTOR-11
Title (en)
GROWTH DIFFERENTIATION FACTOR-11
Title (de)
Wachstums-Differenzierungsfaktor 11
Title (fr)
FACTEUR 11 DE DIFFERENTIATION DE CROISSANCE
Publication
Application
Priority
- US 9917252 W 19990728
- US 12392998 A 19980728
Abstract (en)
[origin: WO0006716A1] A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue and bone tissue.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A23L 1/31 (2006.01); A23L 13/00 (2016.01); A61K 31/7088 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 13/12 (2006.01); A61P 19/00 (2006.01); A61P 21/00 (2006.01); C07K 14/475 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP)
A01K 67/0276 (2013.01); A61P 13/12 (2017.12); A61P 19/00 (2017.12); A61P 21/00 (2017.12); C07K 14/475 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2227/10 (2013.01); A01K 2227/105 (2013.01); A01K 2227/30 (2013.01); A01K 2267/02 (2013.01); A01K 2267/03 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0006716 A1 20000210; AU 5327499 A 20000221; AU 765832 B2 20031002; BR 9912548 A 20020129; CA 2336536 A1 20000210; EP 1100887 A1 20010523; EP 1100887 A4 20030115; JP 2002526034 A 20020820; NZ 509609 A 20031128; NZ 528341 A 20050624
DOCDB simple family (application)
US 9917252 W 19990728; AU 5327499 A 19990728; BR 9912548 A 19990728; CA 2336536 A 19990728; EP 99938885 A 19990728; JP 2000562498 A 19990728; NZ 50960999 A 19990728; NZ 52834199 A 19990728