EP 1100926 A1 20010523 - TRIMER OF HIV $i(ENV) GENE EXPRESSION PRODUCT
Title (en)
TRIMER OF HIV $i(ENV) GENE EXPRESSION PRODUCT
Title (de)
TRIMERE DES EXPRESSIONSPRODUKTES DES HIV ENV GENS
Title (fr)
TRIMERE DU PRODUIT D'EXPRESSION DU GENE $i(ENV) DE HIV
Publication
Application
Priority
- FR 9901871 W 19990729
- FR 9810027 A 19980731
Abstract (en)
[origin: FR2781676A1] The invention concerns a purified recombinant glycoprotein having the following properties: a) an adherence capacity to CD4; b) an affinity with a anti-gp120 antibody capable of neutralising in vitro HIV cell infection; c) an affinity with an anti-gp41 antibody; d) a trimeric form free from inter-chain disulphide bonds. The invention also concerns a vaccine comprising said purified glycoprotein and an adjuvant. The invention further concerns a method for obtaining said glycoprotein as per Claim 1, which consists in expressing, by means of genetic recombining techniques, a glycoprotein corresponding to the properties a), b) and c) mentioned in Claim 1; purifying it, and subjecting it to steps involving at least a reducing agent, an ionic detergent and/or a neutral detergent in conditions leading to a glycoprotein having said properties.
IPC 1-7
IPC 8 full level
A61P 31/18 (2006.01); C07K 14/16 (2006.01); C12N 15/49 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP US)
A61P 31/18 (2017.12 - EP); C07K 14/005 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US); C12N 2740/16122 (2013.01 - EP US)
Citation (search report)
See references of WO 0008167A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
FR 2781676 A1 20000204; FR 2781676 B1 20040402; AU 5045999 A 20000228; CA 2338020 A1 20000217; EP 1100926 A1 20010523; US 6737067 B1 20040518; WO 0008167 A1 20000217
DOCDB simple family (application)
FR 9810027 A 19980731; AU 5045999 A 19990729; CA 2338020 A 19990729; EP 99934806 A 19990729; FR 9901871 W 19990729; US 74465901 A 20010418