Global Patent Index - EP 1100926 A1

EP 1100926 A1 2001-05-23 - TRIMER OF HIV $i(ENV) GENE EXPRESSION PRODUCT

Title (en)

TRIMER OF HIV $i(ENV) GENE EXPRESSION PRODUCT

Title (de)

TRIMERE DES EXPRESSIONSPRODUKTES DES HIV ENV GENS

Title (fr)

TRIMERE DU PRODUIT D'EXPRESSION DU GENE $i(ENV) DE HIV

Publication

EP 1100926 A1 (FR)

Application

EP 99934806 A

Priority

  • FR 9901871 W
  • FR 9810027 A

Abstract (en)

[origin: FR2781676A1] The invention concerns a purified recombinant glycoprotein having the following properties: a) an adherence capacity to CD4; b) an affinity with a anti-gp120 antibody capable of neutralising in vitro HIV cell infection; c) an affinity with an anti-gp41 antibody; d) a trimeric form free from inter-chain disulphide bonds. The invention also concerns a vaccine comprising said purified glycoprotein and an adjuvant. The invention further concerns a method for obtaining said glycoprotein as per Claim 1, which consists in expressing, by means of genetic recombining techniques, a glycoprotein corresponding to the properties a), b) and c) mentioned in Claim 1; purifying it, and subjecting it to steps involving at least a reducing agent, an ionic detergent and/or a neutral detergent in conditions leading to a glycoprotein having said properties.

IPC 1-7 (main, further and additional classification)

C12N 15/49; A61K 39/21; C07K 14/16; G01N 33/68

IPC 8 full level (invention and additional information)

A61P 31/18 (2006.01); C07K 14/16 (2006.01); C12N 15/49 (2006.01); A61K 39/00 (2006.01)

CPC (invention and additional information)

C07K 14/005 (2013.01); A61K 39/00 (2013.01); C12N 2740/16122 (2013.01)

Citation (search report)

See references of WO 0008167A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2781676 A1 20000204; FR 2781676 B1 20040402; AU 5045999 A 20000228; CA 2338020 A1 20000217; EP 1100926 A1 20010523; US 6737067 B1 20040518; WO 0008167 A1 20000217

INPADOC legal status


2005-06-01 [18W] APPLICATION WITHDRAWN

- Effective date: 20050407

2003-08-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030704

2001-05-23 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010228

2001-05-23 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-23 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI