EP 1100941 A2 20010523 - ANTI-ANGIOGENESIS PLASMIDS AND DELIVERY SYSTEMS, AND METHODS OF MAKING AND USING THE SAME

Title (en)

ANTI-ANGIOGENESIS PLASMIDS AND DELIVERY SYSTEMS, AND METHODS OF MAKING AND USING THE SAME

Title (de)

ANTI-ANGIOGENESIS PLASMIDE UND APPLIKATIONSSYSTEME , UND METHODE FÜR IHRE HERSTELLUNG UND VERWENDUNG

Title (fr)

SYSTEMES D'ADMINISTRATION ET PLASMIDES ANTI-ANGIOGENESE ET LEURS PROCEDES DE PREPARATION ET D'UTILISATION

Publication

EP 1100941 A2 20010523 (EN)

Application

EP 99938769 A 19990720

Priority

US 9916388 W 19990720
US 9437598 P 19980727

Abstract (en)

[origin: WO0006759A2] The present invention relates to gene delivery and gene therapy, and provides novel nucleic acid constructs for expression of anti-angiogenic agents in a mammal, formualtions for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs for delivery of therapeutic anti-angiogenic encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (including combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.

IPC 1-7

C12N 15/85; C12N 15/55; C12N 15/12; C12N 15/88; A61K 48/00

IPC 8 full level

A61K 38/00 (2006.01); A61K 47/18 (2006.01); A61K 47/32 (2006.01); A61K 47/44 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/78 (2006.01); C12N 5/10 (2006.01); C12N 9/68 (2006.01); C12N 15/09 (2006.01); C12N 15/55 (2006.01); C12N 15/85 (2006.01); C12N 15/88 (2006.01)

CPC (source: EP)

A61P 35/00 (2017.12); C07K 14/78 (2013.01); C12N 9/6435 (2013.01); C12N 15/85 (2013.01); C12N 15/88 (2013.01); C12Y 304/21007 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12N 2830/007 (2013.01); C12N 2830/008 (2013.01); C12N 2830/15 (2013.01); C12N 2830/42 (2013.01); C12N 2830/85 (2013.01); C12N 2840/203 (2013.01)

Citation (search report)

See references of WO 0006759A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0006759 A2 20000210; WO 0006759 A3 20000622; AU 5318299 A 20000221; CA 2337496 A1 20000210; EP 1100941 A2 20010523; JP 2002524036 A 20020806

DOCDB simple family (application)

US 9916388 W 19990720; AU 5318299 A 19990720; CA 2337496 A 19990720; EP 99938769 A 19990720; JP 2000562541 A 19990720