EP 1100950 A1 20010523 - GASTROINTESTINAL BACTERIAL ANTIBODY FACTORIES
Title (en)
GASTROINTESTINAL BACTERIAL ANTIBODY FACTORIES
Title (de)
ANTIKÖRPERFABRIKEN GASTROINTESTINALER BAKTERIEN
Title (fr)
USINES D'ANTICORPS BACTERIENS GASTRO-INTESTINAUX
Publication
Application
Priority
- US 9917296 W 19990729
- US 9469798 P 19980730
Abstract (en)
[origin: WO0006764A1] Neonates during their first thirty days of life are particularly susceptible to pathogens because their immune system is not yet fully functional. Adults may also be unusually susceptible to pathogens when their immune system has been compromised by disease or when they have been acutely exposed to a bolus of GI pathogen. The invention provides a method of immunizing neonates and adults to pathogens by orally administering recombinant probiotic bacteria that express antibodies to the pathogens. These recombinant bacteria may be optionally administered with antibodies immunologically specific to the pathogens. The invention further provides a composition of recombinant probiotic bacteria that express antibodies to pathogen, and a method to use this composition to immunize neonates and adults.
IPC 1-7
IPC 8 full level
A61K 35/74 (2006.01); C12N 15/09 (2006.01); A61K 39/07 (2006.01); A61K 39/108 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 1/00 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); C07K 16/10 (2006.01); C12N 1/21 (2006.01); A61K 39/00 (2006.01); C12R 1/225 (2006.01)
CPC (source: EP)
A61P 1/00 (2018.01); A61P 31/04 (2018.01); A61P 31/12 (2018.01); C07K 16/10 (2013.01); A61K 2039/505 (2013.01); A61K 2039/542 (2013.01); C07K 2317/622 (2013.01); Y02A 50/30 (2018.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0006764 A1 20000210; AU 5328599 A 20000221; CA 2338001 A1 20000210; EP 1100950 A1 20010523; EP 1100950 A4 20021016; IL 141142 A0 20020210; JP 2002521494 A 20020716
DOCDB simple family (application)
US 9917296 W 19990729; AU 5328599 A 19990729; CA 2338001 A 19990729; EP 99938901 A 19990729; IL 14114299 A 19990729; JP 2000562546 A 19990729