EP 1101772 A1 20010523 - Antibody specific to interleukin 18 precursor
Title (en)
Antibody specific to interleukin 18 precursor
Title (de)
Antikörper spezifisch für den Interleukin-18 Vorläufer
Title (fr)
Anticorps contre le précurseur de l'interleukine-18
Publication
Application
Priority
JP 32486099 A 19991116
Abstract (en)
Disclosed are an antibody specific to interleukin 18 (IL-18) precursor, preparation processes therefor, and uses thereof. The antibody includes immunoglobulins in both forms of polyclonal and monoclonal antibodies which exhibits an immunoreactivity against IL-18 precursor at an intensity higher than against other substances. The antibody is useful in detection and purification of IL-18 precursor and in elimination and detoxification of the precursor accumulated in vivo. The detection method using the antibody is effective in qualitative and quantitative analyses for the precursor as well as in correction of imprecise results caused by assays using anti-IL-18 antibody which exhibits a cross reactivity against the precursor. <IMAGE>
IPC 1-7
IPC 8 full level
C07K 16/24 (2006.01); C12N 5/20 (2006.01)
CPC (source: EP US)
C07K 16/244 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP US)
Citation (search report)
- [A] EP 0850952 A1 19980701 - HAYASHIBARA BIOCHEM LAB [JP]
- [A] EP 0821005 A2 19980128 - HAYASHIBARA BIOCHEM LAB [JP]
- [A] WO 9810072 A1 19980312 - CORNELL RES FOUNDATION INC [US]
- [A] WO 9909063 A1 19990225 - YEDA RES & DEV [IL], et al
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- [DA] K. AKITA ET AL.: "Involvement of caspase-1 and caspase-3 in the production and procesing of mature human interleukin-18 in monocytic THP.1 cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 42, 17 October 1997 (1997-10-17), Baltimore, MD, USA, pages 26595 - 26603, XP002159798
- [DA] H. OKAMURA ET AL.: "Cloning of a new cytokine that induces IFN-gamma production by T cells.", NATURE, vol. 378, no. 6552, 2 November 1995 (1995-11-02), London, GB, pages 88 - 91, XP002024313
- [DA] S. USHIO ET AL.: "Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.", THE JOURNAL OF IMMUNOLOGY, vol. 156, no. 11, 1 June 1996 (1996-06-01), Baltimore, MD, USA, pages 4274 - 4279, XP002022861
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
EP 1101772 A1 20010523; EP 1101772 B1 20090121; CA 2324168 A1 20010516; DE 60041432 D1 20090312; US 2006073519 A1 20060406
DOCDB simple family (application)
EP 00310121 A 20001115; CA 2324168 A 20001115; DE 60041432 T 20001115; US 22410605 A 20050913