Global Patent Index - EP 1102842 A2

EP 1102842 A2 2001-05-30 - ANTISENSE OLIGONUCLEOTIDES FOR THE INHIBITION OF VEGF EXPRESSION

Title (en)

ANTISENSE OLIGONUCLEOTIDES FOR THE INHIBITION OF VEGF EXPRESSION

Title (de)

ANTISENSE OLIGONUKLEOTIDE ZUR HEMMUNG DER VEGF-EXPRESSION

Title (fr)

OLIGONUCLEOTIDES ANTISENS DESTINES A INHIBER L'EXPRESSION DE VEGF

Publication

EP 1102842 A2 (EN)

Application

EP 99938373 A

Priority

  • EP 99938373 A
  • EP 9905432 W
  • EP 98114854 A

Abstract (en)

[origin: EP0978561A1] The present invention relates to an oligonucleotide or a derivative thereof which has a sequence that corresponds to a part of a nucleic acid which encodes VEGF (vascular endothelial growth factor) and which has the ability to inhibit tumor growth in animal tumor models, the invention further relates to the preparation of such oligonucleotide and the use thereof. An oligonucleotide or a derivative thereof which has the sequence SEQ ID NO. 4 or a part thereof, wherein SEQ ID NO. 4 is 3'-GTACCTACAGATAGTCGCGTCGATGACGGTAGG-5 @ , with the first proviso, that not all internucleoside bridges in the oligonucleotide are phosphodiester internucleoside bridges and not all phosphodiester internucleoside bridges are replaced by phosphorothioate internucleoside bridges and/or the second proviso, that the oligonucleotide contains no modified nucleosides selected from C5-propynyl uridine, C5-propynyl cytidine, C5-hexynyl uridine, C5-hexynyl cytidine, 6-aza uridine and 6-aza cytidine.

IPC 1-7 (main, further and additional classification)

C12N 15/11; A61K 31/70; C07H 21/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); A61P 13/12 (2006.01); A61P 17/06 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01); C07H 21/00 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 15/1136 (2013.01); A61K 38/00 (2013.01); C12N 2310/31 (2013.01); C12N 2310/315 (2013.01); C12N 2310/318 (2013.01); C12N 2310/32 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/33 (2013.01); C12N 2310/346 (2013.01)

Combination set (CPC)

C12N 2310/321 + C12N 2310/3521

Citation (search report)

See references of WO 0008140A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

EP 0978561 A1 20000209; AU 5289399 A 20000228; CA 2339340 A1 20000217; EP 1102842 A2 20010530; HU 0103290 A2 20011228; JP 2002523335 A 20020730; PL 346162 A1 20020128; WO 0008140 A2 20000217; WO 0008140 A3 20000518

INPADOC legal status


2001-08-29 [18W] APPLICATION WITHDRAWN

- Date of withdrawal: 20010704

2001-05-30 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010307

2001-05-30 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-30 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI