EP 1104460 A1 20010606 - MODULATION OF APOPTOSIS WITH BID
Title (en)
MODULATION OF APOPTOSIS WITH BID
Title (de)
MODULIERUNG VON APOPTOSE MIT BID
Title (fr)
MODULATION DE L'APOPTOSE A L'AIDE DE BID
Publication
Application
Priority
- US 9916966 W 19990728
- US 13687998 A 19980819
- US 13703898 A 19980820
Abstract (en)
[origin: WO0011162A1] A novel p15 BID polypeptide having cell death agonist activity is disclosed. The p15 BID polypeptide is produced by caspase-cleavage of BID in cells undergoing cell death mediated by TNF or FAS receptors. The p15 BID is useful in methods for modulating death of a target cell which comprise treating the cell with p15 BID. Methods for inhibiting cell death are also described which involve treating a target cell with a mutant p15 BID lacking cell death agonist activity.
IPC 1-7
C12N 15/12; C12N 15/85; C12N 5/10; C12N 9/64; C07K 14/47; A61K 38/17; A61K 48/00
IPC 8 full level
C07K 14/47 (2006.01); C12N 9/64 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
C07K 14/4747 (2013.01); C12N 9/6475 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
See references of WO 0011162A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0011162 A1 20000302; AU 5233799 A 20000314; EP 1104460 A1 20010606
DOCDB simple family (application)
US 9916966 W 19990728; AU 5233799 A 19990728; EP 99937522 A 19990728