EP 1105098 B8 20071003 - LIPOSOMAL THERAPEUTIC COMPOSITIONS AN AMMONIUM SULPHATE GRADIENT PREPARED USING
Title (en)
LIPOSOMAL THERAPEUTIC COMPOSITIONS AN AMMONIUM SULPHATE GRADIENT PREPARED USING
Title (de)
MITTELS AMMONIUMSULFATGRADIENT HERGESTELLTE LIPOSOMALE ANALGETISCHE ZUSAMMENSETZUNGEN
Title (fr)
COMPOSITIONS ANALGÉSIQUES LIPOSOMALES SUSCEPTIBLES D'ÊTRE OBTENUES AU MOYEN D'UN GRADIENT DE SULFATE D'AMMONIUM
Publication
Application
Priority
- US 9918411 W 19990811
- US 9633198 P 19980812
Abstract (en)
[origin: US7357944B2] Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising 'GMV' (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
IPC 8 full level
A61K 9/127 (2006.01); A61K 31/445 (2006.01); A61K 47/02 (2006.01); A61K 47/44 (2006.01); A61P 23/02 (2006.01); A63B 21/005 (2006.01); A63B 21/22 (2006.01); A63B 22/04 (2006.01); A63B 23/04 (2006.01); A61H 1/02 (2006.01); A63B 21/00 (2006.01); A63B 23/035 (2006.01)
CPC (source: EP US)
A61K 9/127 (2013.01 - EP US); A61K 31/445 (2013.01 - EP US); A61P 23/02 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0009089 A1 20000224; AT E355827 T1 20070315; AU 5559799 A 20000306; AU 754559 B2 20021121; CA 2340118 A1 20000224; CA 2340118 C 20090113; DE 69935435 D1 20070419; DE 69935435 T2 20071206; EP 1105098 A1 20010613; EP 1105098 B1 20070307; EP 1105098 B8 20071003; ES 2284266 T3 20071101; IL 140892 A0 20020210; IL 140892 A 20100415; JP 2002522470 A 20020723; JP 4740455 B2 20110803; US 2004156891 A1 20040812; US 6162462 A 20001219; US 6696080 B1 20040224; US 7357944 B2 20080415
DOCDB simple family (application)
US 9918411 W 19990811; AT 99942157 T 19990811; AU 5559799 A 19990811; CA 2340118 A 19990811; DE 69935435 T 19990811; EP 99942157 A 19990811; ES 99942157 T 19990811; IL 14089201 A 20010110; IL 14089299 A 19990811; JP 2000564592 A 19990811; US 37236099 A 19990811; US 71199100 A 20001113; US 77130504 A 20040205