EP 1109809 B1 20041117 - PYRROLOQUINOLINES FOR TREATMENT OF OBESITY
Title (en)
PYRROLOQUINOLINES FOR TREATMENT OF OBESITY
Title (de)
Pyrrolochinoline zur Behandlung von Fettleibigkeit
Title (fr)
PYRROLOLOQUINOLINES DESTINEES AU TRAITEMENT DE L'OBESITE
Publication
Application
Priority
- GB 9902887 W 19990901
- GB 9819019 A 19980901
Abstract (en)
[origin: WO0012502A1] A chemical compound of formula (I), wherein R1 to R3 are independently selected from hydrogen and alkyl; R4 is selected from hydrogen, alkyl, alkoxy, formyl and cyano; X1 is selected from N and C-R7; X2 is selected from N and C-R8; X3 is selected from N and C-R9; X4 is selected from N and C-R10; wherein at least one of X1, X2, X3 and X4 is N; and R5 to R10 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus; and sleep apnea, and particularly for the treatment of obesity.
IPC 1-7
IPC 8 full level
A61K 31/4745 (2006.01); A61P 1/00 (2006.01); A61P 3/04 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 13/00 (2006.01); A61P 15/00 (2006.01); A61P 25/00 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 31/00 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP US)
A61P 1/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 25/30 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 471/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0012502 A1 20000309; AT E282613 T1 20041215; AU 5637799 A 20000321; CA 2341986 A1 20000309; DE 69922024 D1 20041223; DE 69922024 T2 20050915; DK 1109809 T3 20050314; EP 1109809 A1 20010627; EP 1109809 B1 20041117; ES 2232168 T3 20050516; GB 9819019 D0 19981028; JP 2002523506 A 20020730; PT 1109809 E 20050228; US 6365598 B1 20020402
DOCDB simple family (application)
GB 9902887 W 19990901; AT 99943093 T 19990901; AU 5637799 A 19990901; CA 2341986 A 19990901; DE 69922024 T 19990901; DK 99943093 T 19990901; EP 99943093 A 19990901; ES 99943093 T 19990901; GB 9819019 A 19980901; JP 2000567530 A 19990901; PT 99943093 T 19990901; US 78615901 A 20010301