EP 1109811 B1 20030806 - PYRROLOBENZODIAZEPINES
Title (en)
PYRROLOBENZODIAZEPINES
Title (de)
PYRROLOBENZODIAZEPINE
Title (fr)
PYRROLO-BENZODIAZEPINES
Publication
Application
Priority
- GB 9902837 W 19990827
- GB 9818731 A 19980827
Abstract (en)
[origin: WO0012507A2] A compound with formula (I) where R10 is a therapeutically removable nitrogen protecting group; R2 and R3 are independently selected from: H, R, OH, OR, =O, =CH-R, =CH2, CH2-CO2R, CH2-CO2H, CH2-SO2R, O-SO2-R, CO2R, COR and CN; R6, R7 and R9 are independently selected from H, R, OH, OR, halo, amino, nitro, Me3Sn; X is S, O or NH; R11 is either H or R; and where there is optionally a double bond between C1 and C2 or C2 and C3; and R8 is selected from H, R, OH, OR, halo, amino, nitro, Me3Sn, or R7 and R8 together form a group -O-(CH2)p-O-, where p is 1 or 2. Such compounds may be used in methods of ADEPT, GDEPT, NPEPT or PDT.
IPC 1-7
IPC 8 full level
A61K 31/5517 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 33/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 207/08 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01)
CPC (source: EP US)
A61P 31/10 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 33/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 487/04 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0012507 A2 20000309; WO 0012507 A3 20000831; WO 0012507 A8 20001019; AT E246687 T1 20030815; CA 2341968 A1 20000309; CA 2341968 C 20090407; DE 69910227 D1 20030911; DE 69910227 T2 20040617; DK 1109811 T3 20031124; EP 1109811 A2 20010627; EP 1109811 B1 20030806; ES 2205872 T3 20040501; GB 9818731 D0 19981021; JP 2002525284 A 20020813; JP 4669611 B2 20110413; NZ 510492 A 20030829; PT 1109811 E 20031231; US 2003195196 A1 20031016; US 6562806 B1 20030513
DOCDB simple family (application)
GB 9902837 W 19990827; AT 99941766 T 19990827; CA 2341968 A 19990827; DE 69910227 T 19990827; DK 99941766 T 19990827; EP 99941766 A 19990827; ES 99941766 T 19990827; GB 9818731 A 19980827; JP 2000571053 A 19990827; NZ 51049299 A 19990827; PT 99941766 T 19990827; US 37904903 A 20030304; US 76381401 A 20010226