Global Patent Index - EP 1109811 B1

EP 1109811 B1 20030806 - PYRROLOBENZODIAZEPINES

Title (en)

PYRROLOBENZODIAZEPINES

Title (de)

PYRROLOBENZODIAZEPINE

Title (fr)

PYRROLO-BENZODIAZEPINES

Publication

EP 1109811 B1 20030806 (EN)

Application

EP 99941766 A 19990827

Priority

  • GB 9902837 W 19990827
  • GB 9818731 A 19980827

Abstract (en)

[origin: US2003195196A1] A compound with formula (I) where R<subscript>10 </highlight>is a therapeutically removable nitrogen protecting group; R<subscript>2 </highlight>and R<subscript>3 </highlight>are independently selected from: H, R, OH, OR, =O, =CH-R, =CH<subscript>2</highlight>, CH<subscript>2</highlight>-CO<subscript>2</highlight>R, CH<subscript>2</highlight>-CO<subscript>2</highlight>H, CH<subscript>2</highlight>-SO<subscript>2</highlight>R, O-SO<subscript>2</highlight>-R, CO<subscript>2</highlight>R, COR and CN; R<subscript>6</highlight>, R<subscript>7 </highlight>and R<subscript>9 </highlight>are independently selected from H, R, OH, OR, halo, amino, nitro, Me<subscript>3</highlight>Sn; X is S, O or NH; R<subscript>11 </highlight>is either H or R; and where there is optionally a double bond between C1 and C2 or C2 and C3; and R<subscript>8 </highlight>is selected from H, R, OH, OR, halo, amino, nitro, Me<subscript>3</highlight>Sn, or R<subscript>7 </highlight>and R<subscript>8 </highlight>together form a group -O-(CH<subscript>2</highlight>)<subscript>p</highlight>-O-, where p is 1 or 2. Such compounds may be used in methods of ADEPT, GDEPT, NPEPT or PDT.

IPC 1-7

C07D 487/04; A61K 31/5517; C07D 519/00

IPC 8 full level

A61K 31/5517 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 33/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 207/08 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01)

CPC (source: EP US)

A61P 31/10 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 33/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 487/04 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0012507 A2 20000309; WO 0012507 A3 20000831; WO 0012507 A8 20001019; AT E246687 T1 20030815; CA 2341968 A1 20000309; CA 2341968 C 20090407; DE 69910227 D1 20030911; DE 69910227 T2 20040617; DK 1109811 T3 20031124; EP 1109811 A2 20010627; EP 1109811 B1 20030806; ES 2205872 T3 20040501; GB 9818731 D0 19981021; JP 2002525284 A 20020813; JP 4669611 B2 20110413; NZ 510492 A 20030829; PT 1109811 E 20031231; US 2003195196 A1 20031016; US 6562806 B1 20030513

DOCDB simple family (application)

GB 9902837 W 19990827; AT 99941766 T 19990827; CA 2341968 A 19990827; DE 69910227 T 19990827; DK 99941766 T 19990827; EP 99941766 A 19990827; ES 99941766 T 19990827; GB 9818731 A 19980827; JP 2000571053 A 19990827; NZ 51049299 A 19990827; PT 99941766 T 19990827; US 37904903 A 20030304; US 76381401 A 20010226