EP 1109887 A1 20010627 - PRODUCTION AND USE OF DOPAMINERGIC CELLS TO TREAT DOPAMINERGIC DEFICIENCIES
Title (en)
PRODUCTION AND USE OF DOPAMINERGIC CELLS TO TREAT DOPAMINERGIC DEFICIENCIES
Title (de)
PRODUKTION UND VERWENDUNG VON DOPAMINERGISCHEN ZELLEN FÜR DIE BEHANDLUNG VON DOPAMINERGISCHEN DEFIZIENZEN.
Title (fr)
PRODUCTION ET UTILISATION DE CELLULES DOPAMINERGIQUES POUR TRAITER DES DEFICIENCES DOPAMINERGIQUES
Publication
Application
Priority
- US 9823977 W 19981110
- US 9451598 P 19980729
Abstract (en)
[origin: WO0006700A1] Differentiated neuronal cells suitable for transplantation in individuals with a dopamine deficiency are derived from progenitor cells. The progenitor cells are treated with at least one inducing agent such as retinoic acid for a time period sufficient to optimize expression of tyrosine hydroxylase. The cells intended for transplantation are optionally treated with a lithium salt to enhance bcl-2 production and survival. Optionally, the progenitor cells may be co-cultured with Sertoli cells, astrocytes, glial cells, accessory cells or a combination thereof. The transplantation-ready cells are isolated and harvested. The resulting neuronal cells are highly purified and have a phenotype optimized for a dopaminergic deficiency, such as Parkinson's Disease.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C12N 5/0793 (2010.01); A61K 35/12 (2015.01)
CPC (source: EP)
A01K 67/0271 (2013.01); C12N 5/0619 (2013.01); A61K 35/12 (2013.01); C12N 2500/12 (2013.01); C12N 2501/48 (2013.01); C12N 2502/246 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI NL SE
DOCDB simple family (publication)
WO 0006700 A1 20000210; EP 1109887 A1 20010627; EP 1109887 A4 20030521
DOCDB simple family (application)
US 9823977 W 19981110; EP 98959412 A 19981110