Global Patent Index - EP 1109896 A1

EP 1109896 A1 20010627 - ADENOVIRUS FORMULATIONS FOR GENE THERAPY

Title (en)

ADENOVIRUS FORMULATIONS FOR GENE THERAPY

Title (de)

ADENOVIRALE FORMULIERUNGEN ZUR GENTHERAPIE

Title (fr)

FORMULATIONS D'ADENOVIRUS POUR THERAPIE GENIQUE

Publication

EP 1109896 A1 20010627 (EN)

Application

EP 99941147 A 19990813

Priority

  • US 9918515 W 19990813
  • US 9660098 P 19980814

Abstract (en)

[origin: WO0009675A1] The present invention relates to a formulation allowing the preservation of viral particles and viral vectors, which is directly injectable into an organism. It relates more particularly to a formulation for the preservation of a recombinant adenovirus vector that optimally enhances the vector titer, or stabilizes the vector at refrigerator or room temperature, or both. The invention relates to compositions comprising a recombinant adenovirus vector and a concentration of human serum albumin (HSA) effective to stabilize the adenovirus vector at a temperature above the freezing point of water or to enhance a titer of the adenovirus vector compared to a titer in the absence of HSA, or both, in an aqueous buffer.

IPC 1-7

C12N 15/00; C12N 15/63; A61K 48/00; A61K 35/00; C07H 21/04

IPC 8 full level

C12N 15/00 (2006.01); C12N 15/09 (2006.01); A61K 35/00 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 47/10 (2006.01); A61K 47/26 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12N 15/86 (2006.01); C12N 15/861 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 25/00 (2017.12); A61P 35/00 (2017.12); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10351 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

LT SI

DOCDB simple family (publication)

WO 0009675 A1 20000224; WO 0009675 A9 20000803; AU 5485899 A 20000306; AU 748523 B2 20020606; CA 2340682 A1 20000224; EP 1109896 A1 20010627; EP 1109896 A4 20051102; JP 2003528029 A 20030924; MX PA01001727 A 20011127

DOCDB simple family (application)

US 9918515 W 19990813; AU 5485899 A 19990813; CA 2340682 A 19990813; EP 99941147 A 19990813; JP 2000565112 A 19990813; MX PA01001727 A 19990813