EP 1112080 A4 20021024 - REGULATION OF HER2/neu ONCOGENE EXPRESSION BY SYNTHETIC POLYAMIDES
Title (en)
REGULATION OF HER2/neu ONCOGENE EXPRESSION BY SYNTHETIC POLYAMIDES
Title (de)
REGULATION DER HER2/neu ONKOGEN EXPRESSION MITTELS SYNTHETISCHER POLYAMIDE
Title (fr)
REGULATION DE L'EXPRESSION D'ONCOGENE HER2/neu A L'AIDE DE POLYAMIDES SYNTHETIQUES
Publication
Application
Priority
- US 9920971 W 19990910
- US 9990698 P 19980911
Abstract (en)
[origin: WO0015242A1] Methods and compositions comprising polyamides capable of binding the minor groove of double-stranded DNA are described for the inhibition or reduction or gene transcription and expression. The polyamides comprise at least four complementary pairs of aromatic carboxamide residues which are selected to specifically contact and/or bind to the nucleotide sequence of a double-stranded DNA target in the promoter region of the target gene. The methods, compositions, and polyamides are disclosed for the inhibition of oncogene transcription and expression as well as the treatment of cancer.
IPC 1-7
A61K 38/00; A61K 38/04; A61K 38/08; C12Q 1/68; C12N 5/00; C12N 5/06
IPC 8 full level
A61K 31/785 (2006.01); A61K 31/00 (2006.01); A61K 31/4178 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/4178 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
- [XD] WO 9835702 A1 19980820 - CALIFORNIA INST OF TECHN [US], et al
- [AD] WHITE S ET AL: "RECOGNITION OF THE FOUR WATSON-CRICK BASE PAIRS IN THE DNA MINOR GROOVE BY SYNTHETIC LIGANDS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 391, no. 6666, 29 January 1998 (1998-01-29), pages 468 - 471, XP002072062, ISSN: 0028-0836
- See references of WO 0015242A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0015242 A1 20000323; AU 6034199 A 20000403; AU 6496599 A 20000403; AU 768405 B2 20031211; CA 2343289 A1 20000323; CA 2344654 A1 20000323; EP 1112080 A1 20010704; EP 1112080 A4 20021024; EP 1162961 A2 20011219; JP 2002524501 A 20020806; JP 2002524525 A 20020806; WO 0015209 A2 20000323; WO 0015209 A3 20000525
DOCDB simple family (application)
US 9920971 W 19990910; AU 6034199 A 19990910; AU 6496599 A 19990910; CA 2343289 A 19990910; CA 2344654 A 19990910; EP 99952908 A 19990910; EP 99969022 A 19990910; JP 2000569793 A 19990910; JP 2000569826 A 19990910; US 9920840 W 19990910