EP 1112247 B1 20030416 - A PROCESS FOR THE PREPARATION OF S-N,N'-BIS 2-HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- (2-HYDROXY-1- OXOPROPYL) AMINO]-2,4,6- TRIIODO-1,3- BENZENEDICARBOXAMIDE

Title (en)

A PROCESS FOR THE PREPARATION OF S-N,N'-BIS 2-HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- (2-HYDROXY-1- OXOPROPYL) AMINO]-2,4,6- TRIIODO-1,3- BENZENEDICARBOXAMIDE

Title (de)

VERFAHREN ZUR HERSTELLUNG VON S-N, N'-BIS[2-HYDROXY-1-(HYDROXYMETHYL)ETHYL]- 5-[(2-HYDROXY-1-OXOPROPYL)AMINO]-2, 4, 6-TRIIODO-1, 3-BENZDICARBOXAMID

Title (fr)

PROCEDE DE PREPARATION DE S-N,N'-BIS 2-HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- (2-HYDROXY-1- OXOPROPYL) AMINO]-2,4,6- TRIIODO-1,3- BENZENEDICARBOXAMIDE

Publication

EP 1112247 B1 20030416 (EN)

Application

EP 99944338 A 19990806

Priority

EP 9905686 W 19990806
IT MI981996 A 19980911

Abstract (en)

[origin: WO0015602A1] A process for the preparation of S-N,N'-bis [2-hydroxy-1- (hydroxymethyl) ethyl]-5- [(2-hydroxy-1- oxopropyl) amino]-2,4,6- triiodo-1,3- benzenedicarboxamide, comprising the reaction of S-(-)-5-[[2- (acetyloxy)-1- oxopropyl] amino]-2,4,6-triiodo- 1,3-benzenedicarboxylic acid dichloride (III) with 2-amino-1,3-propanediol (serinol) without a solvent, followed by hydrolysis of the acetate group.

IPC 1-7

C07C 231/02; C07C 237/46; C07C 231/12; C07C 231/14

IPC 8 full level

C07C 231/02 (2006.01); C07C 231/12 (2006.01); C07C 237/32 (2006.01); C07C 237/46 (2006.01)

CPC (source: EP US)

C07C 231/02 (2013.01 - EP US); C07C 231/12 (2013.01 - EP US)

C-Set (source: EP US)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0015602 A1 20000323; AT E237581 T1 20030515; AU 5731299 A 20000403; AU 755166 B2 20021205; CA 2344496 A1 20000323; CA 2344496 C 20081014; CN 1177810 C 20041201; CN 1323290 A 20011121; DE 69906999 D1 20030522; DE 69906999 T2 20031113; EP 1112247 A1 20010704; EP 1112247 B1 20030416; IT 1302200 B1 20000731; IT MI981996 A0 19980911; IT MI981996 A1 20000311; JP 2002524549 A 20020806; JP 4536925 B2 20100901; NO 20011241 D0 20010312; NO 20011241 L 20010312; NO 327811 B1 20090928; US 6350908 B1 20020226

DOCDB simple family (application)

EP 9905686 W 19990806; AT 99944338 T 19990806; AU 5731299 A 19990806; CA 2344496 A 19990806; CN 99811960 A 19990806; DE 69906999 T 19990806; EP 99944338 A 19990806; IT MI981996 A 19980911; JP 2000570143 A 19990806; NO 20011241 A 20010312; US 78688401 A 20010328