EP 1112267 A2 20010704 - INHIBITION OF ONCOGENE TRANSCRIPTION BY SYNTHETIC POLYAMIDES
Title (en)
INHIBITION OF ONCOGENE TRANSCRIPTION BY SYNTHETIC POLYAMIDES
Title (de)
HEMMUNG DER ONKOGENTRANSKRIPTION DURCH SYNTHETISCHE POLYAMIDE
Title (fr)
INHIBITION DE TRANSCRIPTION D'ONCOGENES PAR DES POLYAMIDES SYNTHETIQUES
Publication
Application
Priority
- US 9920489 W 19990910
- US 9985498 P 19980911
Abstract (en)
[origin: WO0015773A2] Polyamides capable of inhibiting the transcription of oncogenes are provided. Preferred polyamides comprising at least three complementary pairs of aromatic carboxamide residues bind in the minor groove of double-stranded DNA. With regard to each polyamide, the complementary pairing of some or all of the polyamide's aromatic carboxamide residues determines the target nucleotide sequence of an identified dsDNA target in the promoter region of an oncogene.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 403/14 (2006.01); C08G 69/48 (2006.01); C12N 15/09 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 403/14 (2013.01)
Citation (search report)
See references of WO 0015773A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0015773 A2 20000323; WO 0015773 A3 20000817; AU 5910899 A 20000403; CA 2342278 A1 20000323; EP 1112267 A2 20010704; JP 2003505521 A 20030212
DOCDB simple family (application)
US 9920489 W 19990910; AU 5910899 A 19990910; CA 2342278 A 19990910; EP 99946779 A 19990910; JP 2000570300 A 19990910