EP 1114153 A2 20010711 - LYNX, A NOVEL FAMILY OF RECEPTOR LIGANDS IN THE CENTRAL NERVOUS SYSTEM, CORRESPONDING NUCLEIC ACIDS AND PROTEINS AND USES THEROF
Title (en)
LYNX, A NOVEL FAMILY OF RECEPTOR LIGANDS IN THE CENTRAL NERVOUS SYSTEM, CORRESPONDING NUCLEIC ACIDS AND PROTEINS AND USES THEROF
Title (de)
LYNX, EINE NEUE FAMILIE VON REZEPTORLIGANDE IM ZENTRALNERVENSYSTEM, ENTSPRECHENDE NUKLEINSAÜRE UND PROTEINE UND VERWENDUNGEN DAVON
Title (fr)
LYNX, UNE NOUVELLE FAMILLE DE LIGANDS RECEPTEURS DANS LE SYSTEME NERVEUX CENTRAL, ACIDES NUCLEIQUES ET PROTEINES CORRESPONDANTS ET LEURS UTILISATIONS
Publication
Application
Priority
- US 9921702 W 19990920
- US 15692698 A 19980918
- US 32086499 A 19990527
Abstract (en)
[origin: WO0017356A2] The present invention provides a novel family of polypeptides which are ligand-gated channel receptor accessory molecules or ligands, denoted Lynx. This invention provides an isolated polypeptide comprising an amino acid sequence of a Lynx polypeptide in which the amino acid sequence is set forth in SEQ ID NO:2, SEQ ID NO:4 or SEQ ID NO:15, including fragments, mutants, variants, analogs, homologs, or derivatives, thereof. This invention further provides an isolated immunogenic polypeptide comprising an amino acid sequence of a Lynx polypeptide and relates to antibodies of Lynx polypeptides and the use of such antibodies. The invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of a Lynx polypeptide. This invention provides pharmaceutical compositions and diagnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids of the present invention. Assays for compounds which mimic, alter or inactivate the polypeptides of the present invention for use in therapy are also provided. The present invention further relates to methods of isolating Lynx polypeptides and the nucleic acids encoding such polypeptides.
IPC 1-7
C12N 15/12; C12N 15/11; C12N 15/86; C12N 15/52; C12N 9/00; C12N 5/10; C12N 1/21; C12N 1/19; C07K 14/705; C07K 16/28; G01N 33/53; G01N 33/68; A61K 38/17; C12Q 1/68; A61P 25/00
IPC 8 full level
C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/21 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61P 25/00 (2017.12 - EP); C07K 14/47 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C12N 2799/021 (2013.01 - EP US)
Citation (search report)
See references of WO 0017356A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0017356 A2 20000330; WO 0017356 A3 20000817; WO 0017356 A9 20010705; AU 6394399 A 20000410; CA 2343320 A1 20000330; EP 1114153 A2 20010711; US 2010004162 A1 20100107; US 8013118 B2 20110906
DOCDB simple family (application)
US 9921702 W 19990920; AU 6394399 A 19990920; CA 2343320 A 19990920; EP 99951520 A 19990920; US 32235902 A 20021218