EP 1115880 A2 20010718 - METHODS FOR LARGE-SCALE PRODUCTION OF RECOMBINANT AAV VECTORS
Title (en)
METHODS FOR LARGE-SCALE PRODUCTION OF RECOMBINANT AAV VECTORS
Title (de)
METHODEN ZUR HERSTELLUNG VON REKOMBINANTEN AAV-VEKTOREN IN GROSSEM MASSSTAB
Title (fr)
METHODES DE PRODUCTION A GRANDE ECHELLE DE VECTEURS RECOMBINANTS AAV
Publication
Application
Priority
- US 9922052 W 19990922
- US 10150798 P 19980922
Abstract (en)
[origin: WO0017377A2] Disclosed are HSV-1 amplicons that supply all necessary helper functions required for rAAV packaging and methods for their use. These HSV-1 amplicons have been shown to be capable of rescuing and replicating all forms of rAAV genomes including rAAV genomes introduced into cells by infection of rAAV virions, rAAV genomes transfected into cells on plasmids or proviral rAAV genomes integrated into cellular chromosomal DNA. Also provided are methods for preparing high-titer rAAV vector compositions suitable for gene therapy and the delivery of exogenous polynucleotides to selected host cells.
IPC 1-7
IPC 8 full level
C12N 7/01 (2006.01); C12N 15/864 (2006.01); C12N 15/869 (2006.01)
CPC (source: EP)
C12N 15/86 (2013.01); C12N 2710/16643 (2013.01); C12N 2750/14143 (2013.01); C12N 2800/108 (2013.01)
Citation (search report)
See references of WO 0017377A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0017377 A2 20000330; WO 0017377 A3 20000908; AU 1094900 A 20000410; AU 2004218673 A1 20041104; AU 774706 B2 20040708; CA 2347129 A1 20000330; EP 1115880 A2 20010718; NZ 511171 A 20040227; NZ 528942 A 20050324
DOCDB simple family (application)
US 9922052 W 19990922; AU 1094900 A 19990922; AU 2004218673 A 20041007; CA 2347129 A 19990922; EP 99954648 A 19990922; NZ 51117199 A 19990922; NZ 52894299 A 19990922