EP 1116485 A3 20020116 - Instant granulate and process for its preparation
Title (en)
Instant granulate and process for its preparation
Title (de)
Instant-Granulat und Verfahren zu seiner Herstellung
Title (fr)
Granulé instantané et son procédé de préparation
Publication
Application
Priority
CH 332000 A 20000110
Abstract (en)
[origin: EP1116485A2] A pharmaceutical instant granulate based on carrier material granules coated with active substances has either sugar alcohols and soluble hydrocolloids as the carrier materials and is coated with active substance in a specific weight ratio and/or has one carrier material coated with a specific percentage of active substance and a second carrier material coated with remaining active substance and granulated. A pharmaceutical instant granulate comprises granules of at least two soluble carrier materials coated with at least one layer of a (preferably insoluble or difficultly soluble) active substance and has: A) at least one sugar alcohol, especially mannitol or sorbitol, and at least one soluble hydrocolloid, especially maltodextrin, as the carrier materials and 50-120 parts by weight, preferably 60-100 parts by weight, of active substance per part by weight carrier materials; and/or B) 50-80 wt.% of a first carrier material coated with a layer containing only part of the active substance and a second more soluble carrier material coated with the remaining active substance and granulated. An Independent claim is also included for the preparation of the granulate.
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/10 (2006.01); A61K 9/16 (2006.01); A61K 31/198 (2006.01); A61K 47/10 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01)
CPC (source: EP US)
A61K 9/0095 (2013.01 - EP US); A61K 9/1676 (2013.01 - EP US); A61P 3/02 (2017.12 - EP)
Citation (search report)
- [DA] EP 0232277 B1 19900117
- [A] US 5455049 A 19951003 - ANAEBONAM ALOYSIUS O [US], et al
- [A] DE 2618100 A1 19771103 - FRESENIUS CHEM PHARM IND
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
EP 1116485 A2 20010718; EP 1116485 A3 20020116; AT E292958 T1 20050415; AU 3368701 A 20010724; CA 2396223 A1 20010719; CA 2396223 C 20090602; CN 1179720 C 20041215; CN 1394136 A 20030129; DE 60110034 D1 20050519; DE 60110034 T2 20060302; DK 1246610 T3 20050815; EP 1246610 A2 20021009; EP 1246610 B1 20050413; ES 2240405 T3 20051016; JP 2003519649 A 20030624; JP 4959895 B2 20120627; NO 20022875 D0 20020617; NO 20022875 L 20020806; NO 328899 B1 20100607; RU 2002121486 A 20040320; RU 2262336 C2 20051020; US 2002168386 A1 20021114; US 6645529 B2 20031111; WO 0151026 A2 20010719; WO 0151026 A3 20020321
DOCDB simple family (application)
EP 00101924 A 20000201; AT 01905653 T 20010108; AU 3368701 A 20010108; CA 2396223 A 20010108; CN 01803533 A 20010108; DE 60110034 T 20010108; DK 01905653 T 20010108; EP 0100096 W 20010108; EP 01905653 A 20010108; ES 01905653 T 20010108; JP 2001551450 A 20010108; NO 20022875 A 20020617; RU 2002121486 A 20010108; US 85745901 A 20010605