EP 1117646 A1 20010725 - PHENYLALKANOIC ACID DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS
Title (en)
PHENYLALKANOIC ACID DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS
Title (de)
PHENYLALKANSÄURE-DERIVATE VERWENDBAR ALS ALPHA4 INTEGRINS INHIBITOREN
Title (fr)
DERIVES D'ACIDE PHENYLALCANOIQUE COMME INHIBITEURS D'INTEGRINES ALPHA-4
Publication
Application
Priority
- GB 9903243 W 19990930
- GB 9821406 A 19981001
Abstract (en)
[origin: WO0020396A1] Phenylalkanoic acid derivatives of formula (1) are described; wherein Ar<1> is an aromatic or heteroaromatic group; L<1> is a covalent bond or a linker atom or group; A is an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; R is a carboxylic acid (-CO<2>H) or a derivative thereof; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alpha 4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
IPC 1-7
C07D 213/81; C07C 235/80; A61K 31/4427; A61K 31/44; A61K 31/185
IPC 8 full level
C07D 213/79 (2006.01); A61K 31/192 (2006.01); A61K 31/216 (2006.01); A61K 31/4409 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07C 235/38 (2006.01); C07C 237/22 (2006.01); C07D 213/81 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 37/00 (2017.12); C07C 235/38 (2013.01); C07C 237/22 (2013.01); C07D 213/81 (2013.01)
Citation (search report)
See references of WO 0020396A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0020396 A1 20000413; AU 6108399 A 20000426; EP 1117646 A1 20010725; GB 9821406 D0 19981125; JP 2002526533 A 20020820
DOCDB simple family (application)
GB 9903243 W 19990930; AU 6108399 A 19990930; EP 99947708 A 19990930; GB 9821406 A 19981001; JP 2000574513 A 19990930