EP 1117768 A1 20010725 - DNAZYMES AND METHODS FOR TREATING RESTENOSIS
Title (en)
DNAZYMES AND METHODS FOR TREATING RESTENOSIS
Title (de)
DNAZYME UND VERFAHREN ZUR BEHANDLUNG VON RESTENOSEN
Title (fr)
DNAZYMES ET METHODES DE TRAITEMENT DE LA RESTENOSE
Publication
Application
Priority
- IB 9901484 W 19990812
- US 9637498 P 19980813
Abstract (en)
[origin: WO0009672A1] This application provides a DNAzyme which specifically cleaves c-myc mRNA, comprising a 15-nucleotide catalytic domain and two binding domains, one binding domain contiguous with the 5' end of the catalytic domain and the other binding domain contiguous with the 3' end of the catalytic domain. This invention also provides a pharmaceutical composition for inhibiting the onset of restenosis, which comprises the instant DNAzyme and a pharmaceutically acceptable carrier suitable for topical administration. This invention further provides an angioplastic stent for inhibiting the onset of restenosis, which comprises an angioplastic stent operably coated with a prophylactically effective dose of the instant pharmaceutical composition. Finally, this invention provides methods for inhibiting the onset of restenosis in a subject undergoing angioplasty, which comprises topically administering either the instant pharmaceutical composition or angioplastic stent to the subject.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61B 17/00 (2006.01); A61F 2/82 (2013.01); A61K 9/127 (2006.01); A61K 31/7088 (2006.01); A61L 33/00 (2006.01); A61P 9/00 (2006.01); C07H 21/00 (2006.01); C12N 9/00 (2006.01); C12N 15/113 (2010.01)
CPC (source: EP KR)
A61P 9/00 (2017.12 - EP); C12N 9/00 (2013.01 - KR); C12N 15/1135 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0009672 A1 20000224; WO 0009672 A9 20000518; AU 5298499 A 20000306; CA 2340322 A1 20000224; CN 1323344 A 20011121; EP 1117768 A1 20010725; EP 1117768 A4 20030903; JP 2002525037 A 20020813; KR 20010072475 A 20010731; ZA 200101188 B 20020513
DOCDB simple family (application)
IB 9901484 W 19990812; AU 5298499 A 19990812; CA 2340322 A 19990812; CN 99811966 A 19990812; EP 99938479 A 19990812; JP 2000565109 A 19990812; KR 20017001893 A 20010213; ZA 200101188 A 20010212