Global Patent Index - EP 1117768 A4

EP 1117768 A4 20030903 - DNAZYMES AND METHODS FOR TREATING RESTENOSIS

Title (en)

DNAZYMES AND METHODS FOR TREATING RESTENOSIS

Title (de)

DNAZYME UND VERFAHREN ZUR BEHANDLUNG VON RESTENOSEN

Title (fr)

DNAZYMES ET METHODES DE TRAITEMENT DE LA RESTENOSE

Publication

EP 1117768 A4 20030903 (EN)

Application

EP 99938479 A 19990812

Priority

  • IB 9901484 W 19990812
  • US 9637498 P 19980813

Abstract (en)

[origin: WO0009672A1] This application provides a DNAzyme which specifically cleaves c-myc mRNA, comprising a 15-nucleotide catalytic domain and two binding domains, one binding domain contiguous with the 5' end of the catalytic domain and the other binding domain contiguous with the 3' end of the catalytic domain. This invention also provides a pharmaceutical composition for inhibiting the onset of restenosis, which comprises the instant DNAzyme and a pharmaceutically acceptable carrier suitable for topical administration. This invention further provides an angioplastic stent for inhibiting the onset of restenosis, which comprises an angioplastic stent operably coated with a prophylactically effective dose of the instant pharmaceutical composition. Finally, this invention provides methods for inhibiting the onset of restenosis in a subject undergoing angioplasty, which comprises topically administering either the instant pharmaceutical composition or angioplastic stent to the subject.

IPC 1-7

C12N 9/16; A61K 38/46; C12Q 1/68; C12N 15/11

IPC 8 full level

C12N 15/09 (2006.01); A61B 17/00 (2006.01); A61F 2/82 (2013.01); A61K 9/127 (2006.01); A61K 31/7088 (2006.01); A61L 33/00 (2006.01); A61P 9/00 (2006.01); C07H 21/00 (2006.01); C12N 9/00 (2006.01); C12N 15/113 (2010.01)

CPC (source: EP KR)

A61P 9/00 (2017.12 - EP); C12N 9/00 (2013.01 - KR); C12N 15/1135 (2013.01 - EP)

Citation (search report)

  • [Y] WO 9415646 A1 19940721 - UNIV JEFFERSON [US], et al
  • [Y] WO 9531541 A2 19951123 - RIBOZYME PHARM INC [US]
  • [A] WO 9115580 A1 19911017 - RES DEV FOUNDATION [US]
  • [Y] BREAKER R R: "DNA ENZYMES", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 15, May 1997 (1997-05-01), pages 427 - 431, XP002912052, ISSN: 1087-0156
  • [Y] FINKEL T AND EPSTEIN S E: "Gene therapy for vascular disease", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 9, 1 July 1995 (1995-07-01), pages 843 - 851, XP002088122, ISSN: 0892-6638
  • See references of WO 0009672A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0009672 A1 20000224; WO 0009672 A9 20000518; AU 5298499 A 20000306; CA 2340322 A1 20000224; CN 1323344 A 20011121; EP 1117768 A1 20010725; EP 1117768 A4 20030903; JP 2002525037 A 20020813; KR 20010072475 A 20010731; ZA 200101188 B 20020513

DOCDB simple family (application)

IB 9901484 W 19990812; AU 5298499 A 19990812; CA 2340322 A 19990812; CN 99811966 A 19990812; EP 99938479 A 19990812; JP 2000565109 A 19990812; KR 20017001893 A 20010213; ZA 200101188 A 20010212