EP 1119375 A4 20050202 - METHODS AND ADJUVANTS FOR STIMULATING MUCOSAL IMMUNITY
Title (en)
METHODS AND ADJUVANTS FOR STIMULATING MUCOSAL IMMUNITY
Title (de)
VERFAHREN UND ADJUVANTIEN FÜR DIE STIMULIERUNG VON MUKOSALER IMMUNITÄT
Title (fr)
PROCEDES ET ADJUVANTS STIMULANT L'IMMUNITE DES MUQUEUSES
Publication
Application
Priority
- US 9921203 W 19990915
- US 16703998 A 19981005
Abstract (en)
[origin: WO0020039A1] The invention relates to methods for inducing mucosal immunity to an antigen and provides oligonucleotide adjuvants effective in stimulating such immunity against antigens. The adjuvants provided by the invention have little toxicity, are relatively simple to manufacture as compared to cholera toxin and other mucosal adjuvants, and possess the additional advantages of biasing the host immune response toward the Th1 phenotype.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 39/39 (2006.01); A61P 11/00 (2006.01); A61P 27/14 (2006.01); A61P 37/04 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); G01N 33/15 (2006.01); G01N 33/531 (2006.01)
CPC (source: EP)
A61K 39/39 (2013.01); A61P 11/00 (2017.12); A61P 27/14 (2017.12); A61P 37/04 (2017.12); A61K 2039/541 (2013.01); A61K 2039/544 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/57 (2013.01)
Citation (search report)
- [A] WO 9602555 A1 19960201 - UNIV IOWA RES FOUND [US]
- [X] KRIEG ARTHUR M ET AL: "The role of CpG dinucleotides in DNA vaccines", TRENDS IN MICROBIOLOGY, vol. 6, no. 1, January 1998 (1998-01-01), pages 23 - 27, XP000857633, ISSN: 0966-842X
- [X] WEINER GEORGE J ET AL: "Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 20, 1997, pages 10833 - 10837, XP002120387, ISSN: 0027-8424
- [X] DAVIS H L ET AL: "CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JAN 1998, vol. 160, no. 2, 15 January 1998 (1998-01-15), pages 870 - 876, XP002109526, ISSN: 0022-1767
- See references of WO 0020039A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0020039 A1 20000413; WO 0020039 A9 20000921; AU 6249399 A 20000426; AU 776288 B2 20040902; CA 2346452 A1 20000413; EP 1119375 A1 20010801; EP 1119375 A4 20050202; JP 2002526425 A 20020820
DOCDB simple family (application)
US 9921203 W 19990915; AU 6249399 A 19990915; CA 2346452 A 19990915; EP 99949664 A 19990915; JP 2000573397 A 19990915