EP 1121118 A4 20020911 - FORMAMIDES AS THERAPEUTIC AGENTS

Title (en)

FORMAMIDES AS THERAPEUTIC AGENTS

Title (de)

FORMAMIDE ALS THERAPEUTISCHE MITTEL

Title (fr)

AGENTS THERAPEUTIQUES A BASE DE FORMAMIDES

Publication

EP 1121118 A4 20020911 (EN)

Application

EP 99942456 A 19990825

Priority

GB 9818613 A 19980826
US 9919303 W 19990825
US 9795698 P 19980826

Abstract (en)

[origin: WO0012083A1] A familly of compounds having general structural formula (I) where W is a reverse hydroxamic acid group, and R1, R2, R3, R4, R5 and R6 are as described in the specification or a pharmaceutically acceptable salt, solvate, biohydrolyzable ester, biohydrolyzable amide, affinity reagent, or prodrug thereof. Also described are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine.

IPC 1-7

A61K 31/34

IPC 8 full level

A61K 31/165 (2006.01); A61K 31/381 (2006.01); A61K 31/4402 (2006.01); A61P 3/10 (2006.01); A61P 19/02 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07C 259/06 (2006.01); C07D 213/40 (2006.01); C07D 295/13 (2006.01); C07D 333/24 (2006.01)

CPC (source: EP)

A61P 3/10 (2017.12); A61P 19/02 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07C 259/06 (2013.01); C07D 213/40 (2013.01); C07D 295/13 (2013.01); C07D 333/24 (2013.01)

Citation (search report)

[PX] WO 9838179 A1 19980903 - GLAXO GROUP LTD [GB], et al
[X] WO 9703783 A1 19970206 - BRITISH BIOTECH PHARM [GB], et al
[X] WO 9532944 A1 19951207 - BRITISH BIOTECH PHARM [GB], et al
[X] WO 9410990 A1 19940526 - BRITISH BIO TECHNOLOGY [GB], et al
[X] EP 0236872 A2 19870916 - HOFFMANN LA ROCHE [CH]
[X] WO 9719053 A1 19970529 - BRITISH BIOTECH PHARM [GB], et al
[X] US 5239078 A 19930824 - GALARDY RICHARD E [US], et al
[A] WO 0012082 A1 20000309 - GLAXO GROUP LTD [GB], et al
[A] GB 2348198 A 20000927 - GLAXO GROUP LTD [GB]
[X] FOURNIÉ-ZALUSKI; COULAUD AND CO.: "New Bidentates as Full Inhibitors of Enkephalin-Degrading Enzymes: Synthesis and Analgesic Properties", J. MED. CHEM., vol. 28, 1985, pages 1158 - 1169, XP002202645
See references of WO 0012083A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0012083 A1 20000309; AU 5582899 A 20000321; EP 1121118 A1 20010808; EP 1121118 A4 20020911; JP 2002523454 A 20020730

DOCDB simple family (application)

US 9919303 W 19990825; AU 5582899 A 19990825; EP 99942456 A 19990825; JP 2000567200 A 19990825