EP 1121138 A2 20010808 - COMPOSITIONS FOR THE TREATMENT OF ATHEROSCLEROSIS AND RELATED CONDITIONS
Title (en)
COMPOSITIONS FOR THE TREATMENT OF ATHEROSCLEROSIS AND RELATED CONDITIONS
Title (de)
ZUBEREITUNGEN ZUR BEHANDLUNG DER ATHEROSKLEROSE UND VERWANDTEN ZUSTÄNDEN
Title (fr)
NOUVELLES COMPOSITIONS POUR TRAITER L'ATHEROSCLEROSE ET LES ETATS APPARENTES
Publication
Application
Priority
- IL 9900342 W 19990622
- IL 12531698 A 19980713
Abstract (en)
[origin: WO0002569A2] The present invention is related to novel ginger-based compositions for the treatment of atherosclerosis and related conditions. Standardized ginger extracts included as components of the proprietary composition, "ROZ20", were tested in-vivo for their effect on reducing atherogenic modifications of low-density lipoprotein (LDL) and on reducing or substantially preventing the development of atherosclerosis. The study was performed in apolipoprotein E deficient (Eo) mice. At the end of 10 weeks of consumption of 250 microgram/day, "ROZ20", the entire aorta of the mice were examined for atherosclerotic lesions. The mean lesion area of the ROZ20-treated mice was reduced by 67 % in comparison to the lesion area of placebo-treated mice. These results clearly demonstrate that administration of "ROZ20" for a period of 10 weeks to the atherosclerotic Eo mice has a significant beneficial effect in substantially reducing the size and rate of development of atherosclerotic lesions.
IPC 1-7
IPC 8 full level
A61K 31/12 (2006.01); A61K 35/00 (2006.01); A61K 36/9068 (2006.01)
CPC (source: EP)
A61K 31/12 (2013.01); A61K 36/9068 (2013.01)
C-Set (source: EP)
Citation (search report)
See references of WO 0002569A2
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 0002569 A2 20000120; WO 0002569 A3 20010517; AU 4388899 A 20000201; CA 2337753 A1 20000120; EP 1121138 A2 20010808; IL 125316 A0 19990312
DOCDB simple family (application)
IL 9900342 W 19990622; AU 4388899 A 19990622; CA 2337753 A 19990622; EP 99926726 A 19990622; IL 12531698 A 19980713