EP 1121598 A4 20020130 - DETECTION OF PLEIOTROPHIN
Title (en)
DETECTION OF PLEIOTROPHIN
Title (de)
NACHWEIS VON PLEIOTROPHIN
Title (fr)
DETECTION DE PLEIOTROPHINE
Publication
Application
Priority
- US 9923220 W 19991006
- US 10319798 P 19981006
Abstract (en)
[origin: WO0020869A1] The invention relates to a novel method and kit for detecting and measuring pleiotrophin in samples and diagnosing pleiotrophin-positive diseases. The method involves incubating a sample suspected of containing PTN with anti-PTN antibodies and determining the presence of PTN using a sandwich ELISA. Also methods for treating a pleiotrophin-positive disease by administering an anti-PTN antibody or fragment thereof are provided.
IPC 1-7
IPC 8 full level
A61K 39/395 (2006.01); A61P 35/00 (2006.01); G01N 33/574 (2006.01); G01N 33/577 (2006.01); G01N 33/74 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); G01N 33/57488 (2013.01); G01N 33/74 (2013.01); G01N 2500/00 (2013.01); G01N 2800/52 (2013.01)
Citation (search report)
- [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; March 1998 (1998-03-01), DREYFUS JEANNE ET AL: "HB-GAM/pleiotrophin: Localization of mRNA and protein in the chicken developing leg.", XP002184320, Database accession no. PREV199800208351 & INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 42, no. 2, March 1998 (1998-03-01), pages 189 - 198, ISSN: 0214-6282
- [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, BRIGSTOCK D R ET AL: "Pig uterine luminal fluid contains the developmentally regulated neurotrophic factor, pleiotrophin.", XP002184321, Database accession no. PREV199698645742 & JOURNAL OF ENDOCRINOLOGY, vol. 148, no. 1, 1996, pages 103 - 111, ISSN: 0022-0795
- [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, MITSIADIS THIMIOS A ET AL: "Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis.", XP002184322, Database accession no. PREV199598168700 & DEVELOPMENT (CAMBRIDGE), vol. 121, no. 1, 1995, pages 37 - 51, ISSN: 0950-1991
- [XP] ZHANG N ET AL: "Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors", CURRENT OPINION IN HEMATOLOGY, RAPID SCIENCE PUBLISHERS, PHILADELPHIA, PA, US, vol. 6, no. 1, January 1999 (1999-01-01), pages 44 - 50, XP002122375, ISSN: 1065-6251
- See references of WO 0020869A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0020869 A1 20000413; CA 2346406 A1 20000413; CA 2346406 C 20090217; EP 1121598 A1 20010808; EP 1121598 A4 20020130; JP 2002526777 A 20020820
DOCDB simple family (application)
US 9923220 W 19991006; CA 2346406 A 19991006; EP 99951799 A 19991006; JP 2000574936 A 19991006