EP 1123385 A2 20010816 - HUMAN PROTEINS INVOLVED IN ENDOPLASMIC RETICULUM PROTEIN DEGRADATION
Title (en)
HUMAN PROTEINS INVOLVED IN ENDOPLASMIC RETICULUM PROTEIN DEGRADATION
Title (de)
MENSCHLICHE PROTEINE, WELCHES EINE ROLLE BEI DER PROTEINABBAU DES ENDOPLASMATISCHES RETIKULUM SPIELT
Title (fr)
PROTEINES HUMAINES RESPONSABLES DE LA DEGRADATION DU RETICULUM ENDOPLASMIQUE (ER)
Publication
Application
Priority
- US 9924563 W 19991021
- US 10506498 P 19981021
Abstract (en)
[origin: WO0023599A2] The invention relates to degradation of proteins via the ubiquitin-proteasome pathway. More particularly, the invention relates to the degradation of proteins in the ER, including cystic fibrosis transmembrane conductance regulator (CFTR) via the ubiquitin-proteasome pathway. The invention provides methods and compositions for inhibiting such degradation and for promoting the maturation of DELTA F508 into a functional CFTR and for understanding the role of loss of CFTR function in CF. The invention resides in the discovery of human proteins responsible for the ubiquitination of DELTA F508, CFTR, and alpha 1-AT.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/7105 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 11/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 9/00 (2006.01); C12N 15/60 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6883 (2018.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 11/00 (2017.12); A61P 35/00 (2017.12); C12N 9/93 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/158 (2013.01)
Citation (search report)
See references of WO 0023599A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0023599 A2 20000427; WO 0023599 A3 20000914; AU 1127200 A 20000508; CA 2348156 A1 20000427; EP 1123385 A2 20010816; JP 2002527111 A 20020827
DOCDB simple family (application)
US 9924563 W 19991021; AU 1127200 A 19991021; CA 2348156 A 19991021; EP 99955088 A 19991021; JP 2000577306 A 19991021