Global Patent Index - EP 1123400 A1

EP 1123400 A1 20010816 - GENE FOR A THROMBIN INHIBITOR FROM THE TRIATOMA GENUS AND PROTEIN WITH A THROMBIN-INHIBITING EFFECT

Title (en)

GENE FOR A THROMBIN INHIBITOR FROM THE TRIATOMA GENUS AND PROTEIN WITH A THROMBIN-INHIBITING EFFECT

Title (de)

GEN FÜR EINEN THROMBININHIBITOR AUS RAUBWANZEN UND PROTEIN MIT THROMBINHEMMENDER WIRKUNG

Title (fr)

GENE POUR UN INHIBITEUR DE THROMBINE ISSU DE TRIATOMA ET PROTEINE A EFFET INHIBITEUR DE THROMBINE

Publication

EP 1123400 A1 20010816 (DE)

Application

EP 99953879 A 19991019

Priority

  • DE 19848785 A 19981022
  • EP 9907900 W 19991019

Abstract (en)

[origin: DE19848785A1] A protein (I) with thrombin inhibiting activity, is new and has the fully defined 344 amino acid sequence containing, at positions 13 - 117, 125 - 229 and 234 - 342, domains (DI), (DII) and (DIII). A protein (I) with thrombin inhibiting activity, is new and has the fully defined 344 amino acid sequence containing, at positions 13 - 117, 125 - 229 and 234 - 342, domains (DI), (DII) and (DIII) comprising the following sequences: (1) Val Cys Gly Ser Asp Gly Asn Thr Tyr Ser Asn Pro Cys Met Leu Asn Cys (DI, aa 27 - 43); (2) Val Cys Gly Asp Asp Gln Ile Thr Tyr Leu Asn Leu Cys His Leu Glu Cys (DI, aa 80 - 96); (3) Val Cys Gly Ser Asp Gly Asn Thr Tyr Ser Asn Pro Cys Met Leu Thr Cys (DII, aa 139 - 155); (4) Val Cys Gly Asp Asp Glu Ile Thr Tyr Arg Asn Leu Cys His Leu Glu Cys (DII, aa 192 - 208); (5) Val Cys Gly Thr Asp Gly Arg Thr Tyr Pro Asn Ile Cys Val Leu Lys Cys (DIII, aa 248 - 264); and (6) Val Cys Gly Thr Asp Gly Lys Thr Tyr Gly Asn Leu Cys Met Leu Gly Cys (DIII, aa 305 - 321). Independent claims are also included for the following: (1) a recombinant DNA (II) from Dipetalogaster maximus encoding (I), comprising the fully defined 1409 base pair sequence or a derivative that hybridizes to this sequence under stringent conditions, or its antisense sequence; (2) a vector (III) containing an origin of replication, functional in Escherichia coli, promoter and signal peptide sequences and optionally terminator functional in E. coli and (II); and (3) a organism (IV), transformed with (III) and able to produce (I).

IPC 1-7

C12N 15/15; C07K 14/81; C12N 1/21; C12N 15/70

IPC 8 full level

C07K 14/435 (2006.01); C12N 1/21 (2006.01); C12N 15/15 (2006.01)

CPC (source: EP)

C07K 14/43563 (2013.01)

Citation (search report)

See references of WO 0024898A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

DE 19848785 A1 20000427; EP 1123400 A1 20010816; WO 0024898 A1 20000504; WO 0024898 A8 20000921

DOCDB simple family (application)

DE 19848785 A 19981022; EP 9907900 W 19991019; EP 99953879 A 19991019