Global Patent Index - EP 1124985 A4

EP 1124985 A4 20030115 - BIOMARKERS FOR OXIDATIVE STRESS

Title (en)

BIOMARKERS FOR OXIDATIVE STRESS

Title (de)

BIOMARKER FÜR OXIDATIVEN STRESS

Title (fr)

BIOMARQUEURS DU STRESS D'OXYDATION

Publication

EP 1124985 A4 20030115 (EN)

Application

EP 99971864 A 19991105

Priority

  • US 9926133 W 19991105
  • US 10740498 P 19981106

Abstract (en)

[origin: WO0028072A1] This invention relates generally to methods of detecting and quantifying biomarkers of oxidative stress in proteins. The biomarker may be any amino acid that has undergone oxidation (or other modification, e.g. chloro-tyrosine, dityrosine). Emphasis is given herein on oxidized sulfur- or selenium-containing amino acids (SSAA). The biomarker of oxidative stress in proteins may be detected with an antibody that binds to oxidized amino acids, specifically oxidized sulfur- or selenium-containing amino acids. The antibody may be monoclonal or polyclonal. The presence of biomarker or amount of biomarker present in a sample may be used to aid in assessing the efficacy of environmental, nutritional and therapeutic interventions, among other uses.

IPC 1-7

C12Q 1/68; C07C 61/06; C12N 1/21; C12N 9/64; G01N 33/68

IPC 8 full level

C07K 14/47 (2006.01); C07K 14/62 (2006.01); C07K 14/765 (2006.01); C07K 14/775 (2006.01); C12N 1/21 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP)

C07K 14/4723 (2013.01); C07K 14/62 (2013.01); C07K 14/765 (2013.01); C07K 14/775 (2013.01); G01N 33/68 (2013.01)

Citation (search report)

  • [X] WO 9604311 A1 19960215 - UNIV ALABAMA RES FOUND [US]
  • [X] WO 9711371 A1 19970327 - CYTOCHEM INC [US], et al
  • [X] WO 9812561 A1 19980326 - ATHEROGENICS INC [US], et al
  • [X] AHMAD J ET AL: "DETECTION OF OXIDATIVE DNA DAMAGE BY A MONOCLONAL ANTIBODY: ROLE OF LYSYL RESIDUES IN ANTIGEN BINDING", IMMUNOLOGY LETTERS, AMSTERDAM, NL, vol. 62, no. 2, June 1998 (1998-06-01), pages 87 - 92, XP001118007, ISSN: 0165-2478
  • See references of WO 0028072A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0028072 A1 20000518; WO 0028072 A9 20000921; AU 1243500 A 20000529; CA 2348685 A1 20000518; EP 1124985 A1 20010822; EP 1124985 A4 20030115

DOCDB simple family (application)

US 9926133 W 19991105; AU 1243500 A 19991105; CA 2348685 A 19991105; EP 99971864 A 19991105