EP 1125107 A1 20010822 - TESTS FOR THE RAPID EVALUATION OF ISCHEMIC STATES AND KITS
Title (en)
TESTS FOR THE RAPID EVALUATION OF ISCHEMIC STATES AND KITS
Title (de)
TEST ZUR SCHNELLEN BESTIMMUNG VON ISCHÄMISCHEN ZUSTÄNDEN UND TESTSATZ DAFÜR
Title (fr)
EPREUVES PERMETTANT UNE EVALUATION RAPIDE D'ETATS ISCHEMIQUES ET NECESSAIRES A CET EFFET
Publication
Application
Priority
- US 9922905 W 19991001
- US 16558198 A 19981002
- US 16592698 A 19981002
- US 10273898 P 19981002
- US 11539299 P 19990111
Abstract (en)
[origin: CA2344762A1] The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method o f testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin whic h occurs following an ischemic event; methods for detecting and quantifying th is alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumi n to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following a n ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N- terminal Asp residue.
IPC 1-7
G01N 21/00; G01N 21/29; G01N 31/22; G01N 33/543; G01N 33/00; G01N 33/53; C12Q 1/00
IPC 8 full level
G01N 33/68 (2006.01); A61B 5/0402 (2006.01); C07K 16/18 (2006.01); C12N 15/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/00 (2006.01); G01N 21/00 (2006.01); G01N 21/27 (2006.01); G01N 21/29 (2006.01); G01N 21/31 (2006.01); G01N 21/33 (2006.01); G01N 21/35 (2014.01); G01N 21/3577 (2014.01); G01N 21/359 (2014.01); G01N 31/22 (2006.01); G01N 33/00 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP)
G01N 33/6842 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 6409599 A 20000426; AU 769727 B2 20040205; CA 2344762 A1 20000413; CA 2344762 C 20081223; EP 1125107 A1 20010822; EP 1125107 A4 20020417; JP 2002526764 A 20020820
DOCDB simple family (application)
AU 6409599 A 19991001; CA 2344762 A 19991001; EP 99951710 A 19991001; JP 2000574907 A 19991001