EP 1127277 A1 20010829 - POLYGLUTAMINE-CONTAINING PROTEINS IN NEUROPSYCHIATRIC DISORDERS
Title (en)
POLYGLUTAMINE-CONTAINING PROTEINS IN NEUROPSYCHIATRIC DISORDERS
Title (de)
POLYGLUTAMIN ENTHALTENDE PROTEINE IN NEUROPSYCHIATRISCHEN ERKRANKUNGEN
Title (fr)
PROTEINE CONTENANT DE LA POLYGLUTAMINE DANS LES TROUBLES NEUROPSYCHIATRIQUES
Publication
Application
Priority
- CA 9901038 W 19991103
- CA 2252727 A 19981103
Abstract (en)
[origin: WO0026675A1] The present invention relates to diseases caused by CAG repeat expansions. More particularly, the present invention relates to neuropsychiatric diseases caused by CAG repeat expansions and even more particularly to schizophrenia and major depression. In particular, the present invention relates to the identification of at least one protein containing polyglutamine arrays, which acts as a marker for the pathogenesis of a neuropsychiatric disorder and more particularly for schizophrenia and major depression. The present invention further relates to diagnosis and treatment of neuropsychiatric disorders linked to polyglutamine tracts-containing proteins. The present invention further relates to diagnosis and treatment methods of neuropsychiatric disorders based on a targeting of the CAG/CTG repeat expansions encoding a polyglutamine tract. The present invention further provides methods of detecting nucleic acids encoding the polyglutamine tracts in a sample; kits containing nucleic acid probes or ligands of the polyglutamine tract, bio-assays using the nucleic acid sequences, and protein sequences of the present invention or ligands specific thereto to diagnose, assess, or prognose a mammal afflicted with or predisposed to develop a neuropsychiatric disorder linked to the presence of polyglutamine-containing proteins.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/577 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C12Q 1/6883 (2013.01); G01N 33/6896 (2013.01); C12Q 2600/156 (2013.01); G01N 2800/302 (2013.01)
Citation (search report)
See references of WO 0026675A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0026675 A1 20000511; AU 1023000 A 20000522; CA 2252727 A1 20000503; EP 1127277 A1 20010829; JP 2002529706 A 20020910
DOCDB simple family (application)
CA 9901038 W 19991103; AU 1023000 A 19991103; CA 2252727 A 19981103; EP 99953476 A 19991103; JP 2000580005 A 19991103