Global Patent Index - EP 1128839 A4

EP 1128839 A4 20021009 - PHARMACEUTICAL COMPOSITIONS COMPRISING SYNTHETIC PEPTIDE COPOLYMERS AND METHODS FOR PREVENTING AND TREATING GVHD AND HVGD

Title (en)

PHARMACEUTICAL COMPOSITIONS COMPRISING SYNTHETIC PEPTIDE COPOLYMERS AND METHODS FOR PREVENTING AND TREATING GVHD AND HVGD

Title (de)

PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ENTHALTEND KOPOLYMERE SYNTHETISCHER PEPTIDE UND METHODEN ZUR VORBEUGUNG UND BEHANDLUNG VON GVHD UND HVGD

Title (fr)

COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES COPOLYMERES DE PEPTIDES SYNTHETIQUES ET METHODES DE PREVENTION ET DE TRAITEMENT DE LA REACTION DU GREFFON CONTRE L'HOTE (GVHD) ET DE LA REACTION DE L'HOTE CONTRE LE GREFFON (HVGD)

Publication

EP 1128839 A4 20021009 (EN)

Application

EP 99960378 A 19991112

Priority

  • US 9927107 W 19991112
  • US 10818498 P 19981112
  • US 14521999 P 19990723

Abstract (en)

[origin: WO0027417A1] Compositions and methods for treating and preventing host-versus-graft disease and graft-versus-host disease comprising as active ingredient random copolymers of amino acids comprising one amino acid from at least three of the following groups: (a) lysine and arginine; (b) glutamic acid and aspartic acid; (c) alanine and glycine; and (d) tyrosine and tryptophan; with the proviso that the random copolymer is not Copolymer 1 or D-Copolymer 1 when the disease being treated is graft-versus-host disease.

IPC 1-7

C07K 5/00; C07K 7/00; A61K 38/00; C07K 16/00; G01N 33/53

IPC 8 full level

A61K 38/16 (2006.01); A61L 27/22 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61K 38/16 (2013.01); A61L 27/22 (2013.01); A61L 27/227 (2013.01)

Citation (search report)

  • [X] WO 9632119 A1 19961017 - YEDA RES & DEV [IL], et al
  • [A] WO 9531997 A1 19951130 - US ARMY [US], et al
  • [A] WO 9202543 A1 19920220 - CYTEL CORP [US], et al
  • [A] WO 9426774 A1 19941124 - CYTEL CORP [US]
  • [A] WO 9526980 A2 19951012 - IMMULOGIC PHARMA CORP [US]
  • [X] SCHLEGEL P G ET AL: "A SYNTHETIC RANDOM BASIC COPOLYMER WITH PROMISCUOUS BINDING TO CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES INHIBITS T-CELLPROLIFERATIVE RESPONSES TO MAJOR AND MINOR HISTOCOMPATIBILITY ANTIGENS IN VITRO AND CONFERS THE CAPACITY TO PREVENT MURINE GRAFT-VERSUS-HOST DISEASE IN VIVO", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, no. 10, 14 May 1996 (1996-05-14), pages 5061 - 5066, XP000578029, ISSN: 0027-8424
  • [X] FRIDKIS-HARELI M. ET AL.: "Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility comples molecules on living antigen-presenting cells - specificity and promiscuity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 91, 1994, WASHINGTON US, pages 4872 - 4876, XP000891508
  • [XP] FRIDKIS-HARELI M. ET AL.: "Binding of random copolymers of three aminoacids to class II MHC molecules", INTERNATIONAL IMMUNOLOGY, vol. 11, no. 5, May 1999 (1999-05-01), pages 635 - 641, XP000893153
  • [X] LI Q. ET AL.: "Glatiramer acetate blocks the activation of THP-1 cells by interferon-gamma", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 342, 1998, pages 303 - 310, XP000893154
  • [X] TEITELBAUM D ET AL: "CROSS-REACTIONS AND SPECIFICITIES OF MONOCLONAL ANTIBODIES AGAINST MYELIN BASIC PROTEIN AND AGAINST THE SYNTHETIC COPOLYMER1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, November 1991 (1991-11-01), pages 9528 - 9532, XP002949037, ISSN: 0027-8424
  • [X] TEITELBAUM D ET AL: "SYNTHETIC COPOLYMER 1 INHIBITS HUMAN T-CELL LINES SPECIFIC FOR MYELIN BASIC PROTEIN", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, January 1992 (1992-01-01), pages 137 - 141, XP002924839, ISSN: 0027-8424
  • [X] SELA M ET AL: "SUPPRESSIVE ACTIVITY OF COP-1 IN EAE AND ITS RELEVANCE TO MULTIPLE SCLEROSIS", BULL. INST. PASTEUR, vol. 88, 1990, pages 303 - 314, XP002926272
  • [X] TEITELBAUM D ET AL: "SUPPRESSION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY A SYNTHETIC POLYPEPTIDE", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 1, 1971, pages 242,244,246,248, XP002926270, ISSN: 0014-2980
  • [X] TEITELBAUM D ET AL: "COPOLYMER 1 FROM THE LABORATORY TO FDA", ISRAEL JOURNAL OF MEDICAL SCIENCES, ISRAEL MEDICAL ASSOCIATION, TEL AVIV, IL, vol. 33, no. 4, April 1997 (1997-04-01), pages 280 - 284, XP002926268, ISSN: 0021-2180
  • [X] AHARONI RINA ET AL: "Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.", IMMUNOLOGY LETTERS, vol. 58, no. 2, 1997, pages 79 - 87, XP002205821, ISSN: 0165-2478
  • See references of WO 0027417A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0027417 A1 20000518; AU 1727000 A 20000529; AU 775073 B2 20040715; AU 775073 C 20070503; CA 2355400 A1 20000518; EP 1128839 A1 20010905; EP 1128839 A4 20021009

DOCDB simple family (application)

US 9927107 W 19991112; AU 1727000 A 19991112; CA 2355400 A 19991112; EP 99960378 A 19991112