EP 1129201 A1 20010905 - LYSOZYME FUSION PROTEINS IN INFECTIONS
Title (en)
LYSOZYME FUSION PROTEINS IN INFECTIONS
Title (de)
LYSOZYME FUSIONSPROTEINE GEGEN INFEKTIONEN
Title (fr)
TRAITEMENT D'INFECTIONS AU MOYEN DE PROTEINES DE FUSION LYSOZYME
Publication
Application
Priority
- US 9927403 W 19991118
- US 19387798 A 19981118
- US 44074299 A 19991116
Abstract (en)
[origin: WO0029588A1] A method and composition for prophylaxis and/or therapeutic treatment of bacterial infections, particularly respiratory bacterial infections. A fusion protein of lysozyme and the carboxyl terminal propeptide of surfactant protein-B (SP-B) with the preceding ten amino acids of the mature SP-B peptide, or recombinant lysozyme alone, is administered in a pharmaceutically acceptable medium to an individual. The fusion protein or recombinant lysozyme may be selected so as to deliver it to a target infection site, such as the lungs or gastrointestinal tract. The method and composition eliminates problems associated with conventional antibiotic treatments, such as inefficacy and promotion of antibiotic resistant bacterial strains.
IPC 1-7
C12N 15/56; C12N 15/12; C12N 15/62; C12N 9/36; C07K 14/47; A61K 38/47; A61P 11/00; A61P 31/04
IPC 8 full level
C12N 15/09 (2006.01); A61K 9/12 (2006.01); A61K 38/46 (2006.01); A61P 1/00 (2006.01); A61P 11/00 (2006.01); A61P 31/04 (2006.01); C07K 19/00 (2006.01); C12N 9/36 (2006.01); C12N 9/42 (2006.01); C12N 15/56 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 1/00 (2018.01); A61P 11/00 (2018.01); A61P 31/04 (2018.01); C12N 9/2462 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); Y02A 50/30 (2018.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0029588 A1 20000525; AU 2345900 A 20000605; AU 759743 B2 20030501; BR 9915218 A 20010731; CA 2349837 A1 20000525; EP 1129201 A1 20010905; JP 2002530083 A 20020917
DOCDB simple family (application)
US 9927403 W 19991118; AU 2345900 A 19991118; BR 9915218 A 19991118; CA 2349837 A 19991118; EP 99967112 A 19991118; JP 2000582571 A 19991118