Global Patent Index - EP 1131354 A4

EP 1131354 A4 20030102 - CONTRACEPTIVE ANTIBODY VACCINES

Title (en)

CONTRACEPTIVE ANTIBODY VACCINES

Title (de)

IMPFSTOFFE ZUR EMPFÄNGNISVERHÜTUNG BASIEREND AUF ANTIKÖRPERN

Title (fr)

VACCINS CONTRACEPTIFS CONTENANT UN ANTICORPS

Publication

EP 1131354 A4 20030102 (EN)

Application

EP 99960285 A 19991112

Priority

  • US 9926671 W 19991112
  • US 10832598 P 19981113

Abstract (en)

[origin: WO0029443A1] The invention provides an antibody contraceptive vaccine comprising an antibody that has at least one CDR containing a portion of an antigen of a cell or protein associated with reproductive function and which antibody has an enhanced ability to elicit an anti-idiotype response, for example, by substituting one or more variable region cysteine residues that form intrachain disulfide bonds with an amino acid residue that does not have a sulfhydryl group, such that the intrachain disulfide bond does not form. The invention further provides methods of contraception using the antibody contraceptive vaccines of the invention.

IPC 1-7

C07K 16/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 15/18 (2006.01); C07K 16/00 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP)

A61P 15/18 (2017.12); C07K 16/00 (2013.01); A61K 2039/505 (2013.01); C07K 2318/10 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

  • [PY] WO 9925378 A1 19990527 - EURO CELTIQUE SA [US]
  • [A] US 5508386 A 19960416 - ZANETTI MAURIZIO [US], et al
  • [Y] DIEKMAN ALAN B ET AL: "Sperm antigens and their use in the development of an immunocontraceptive.", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 37, no. 1, 1997, pages 111 - 117, XP002049805, ISSN: 1046-7408
  • [A] PROBA KARL ET AL: "A natural antibody missing a cysteine in V-H: Consequences for thermodynamic stability and folding.", JOURNAL OF MOLECULAR BIOLOGY, vol. 265, no. 2, 1997, pages 161 - 172, XP002217911, ISSN: 0022-2836
  • [A] LANGEDIJK ANNETTE C ET AL: "The nature of antibody heavy chain residue H6 strongly influences the stability of a VH domain lacking the disulfide bridge.", JOURNAL OF MOLECULAR BIOLOGY, vol. 283, no. 1, 16 October 1998 (1998-10-16), pages 95 - 110, XP000944533, ISSN: 0022-2836
  • [A] RUDIKOFF S ET AL: "Functional antibody lacking a variable-region disulfide bridge", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 83, October 1986 (1986-10-01), pages 7875 - 7878, XP002142019, ISSN: 0027-8424
  • [A] ZAGHOUANI H ET AL: "Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 259, no. 5092, 8 January 1993 (1993-01-08), pages 224 - 227, XP002177700, ISSN: 0036-8075
  • [A] BRUMEANU T-D ET AL: "Engineering of doubly antigenized immunoglobulins expressing T and B viral epitopes", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 2, 1 June 1996 (1996-06-01), pages 85 - 95, XP004052673, ISSN: 1380-2933
  • See references of WO 0029443A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0029443 A1 20000525; WO 0029443 A9 20010322; AU 1719000 A 20000605; AU 753753 B2 20021024; CA 2350917 A1 20000525; EP 1131354 A1 20010912; EP 1131354 A4 20030102; IL 143100 A0 20020421; JP 2003535021 A 20031125; MX PA01004778 A 20030721

DOCDB simple family (application)

US 9926671 W 19991112; AU 1719000 A 19991112; CA 2350917 A 19991112; EP 99960285 A 19991112; IL 14310099 A 19991112; JP 2000582428 A 19991112; MX PA01004778 A 19991112