EP 1133280 A1 20010919 - METHOD OF PREPARING STABLE SUSPENSIONS OF INSOLUBLE MICROPARTICLES
Title (en)
METHOD OF PREPARING STABLE SUSPENSIONS OF INSOLUBLE MICROPARTICLES
Title (de)
VERFAHREN ZUR HERSTELLUNG STABILER SUSPENSIONEN VON UNLÖSLICHEN MIKROPARTIKELN
Title (fr)
PROCEDE DE PREPARATION DE SUSPENSIONS STABLES DE MICROPARTICULES INSOLUBLES
Publication
Application
Priority
- US 9927435 W 19991119
- US 10920398 P 19981120
Abstract (en)
[origin: WO0030615A1] Sub-micron and micron-size stable particles of water-insoluble or poorly soluble drugs or other industrially useful insoluble compounds suspended in an aqueous medium containing at least one surface modifier are prepared by selecting the surface modifier or modifiers such that the hydrophile-lipophile balance (HLB) of the composition, defined as formula (I): is between 4 and 9. This provides a reliable HLB-based selection criteria for selecting the type and amount of surface modifiers used to obtain sub-micron size stable suspensions.
IPC 1-7
IPC 8 full level
A61K 9/10 (2006.01); A61K 9/14 (2006.01); A61K 47/24 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2006.01); A61K 47/38 (2006.01); A61K 47/44 (2006.01); A61P 5/00 (2006.01); A61P 9/12 (2006.01); A61P 21/02 (2006.01); A61P 23/00 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 29/00 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01)
CPC (source: EP KR)
A61K 9/10 (2013.01 - KR); A61K 9/145 (2013.01 - EP); A61K 9/146 (2013.01 - EP); A61P 5/00 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 21/02 (2017.12 - EP); A61P 23/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/04 (2017.12 - EP); A61P 37/06 (2017.12 - EP)
Citation (search report)
See references of WO 0030615A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0030615 A1 20000602; AU 1737400 A 20000613; AU 767737 B2 20031120; CA 2349202 A1 20000602; CA 2349202 C 20120619; CN 1213733 C 20050810; CN 1337877 A 20020227; EP 1133280 A1 20010919; IL 143196 A0 20020421; IL 143196 A 20120131; JP 2002530320 A 20020917; JP 5296954 B2 20130925; KR 20010075713 A 20010809
DOCDB simple family (application)
US 9927435 W 19991119; AU 1737400 A 19991119; CA 2349202 A 19991119; CN 99815644 A 19991119; EP 99960497 A 19991119; IL 14319601 A 20010517; IL 14319699 A 19991119; JP 2000583499 A 19991119; KR 20017006123 A 20010515