EP 1133508 A2 20010919 - BENZYLGLYCOSYLAMIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION
Title (en)
BENZYLGLYCOSYLAMIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION
Title (de)
BENZYLGLYCOSYLAMIDE ALS INHIBITOREN DER PROLIFERATION VON GLATTEN MUSKELZELLEN
Title (fr)
BENZYLGLYCOSYLAMIDES UTILISES COMME INHIBITEURS DE PROLIFERATION DES CELLULES DU MUSCLE LISSE
Publication
Application
Priority
- US 9927780 W 19991123
- US 19843298 A 19981124
Abstract (en)
[origin: WO0031093A2] This invention provides smooth muscle cell proliferation inhibitors of formula (I) having a structure wherein Y is C or N; where n is 0 - 3; X is (A) wherein R<1>, and R<2> are each independently, hydrogen, alkyl of 1 to 6 carbon atoms, halo, acetyl, phenyl, CF3, CN, OH, NO2, NH2, alkoxy of 1 to 6 carbon atoms, or alkoxynitrile of 1 to 6 carbon atoms; R<3> is hydrogen, acylamide of 2 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms; R<4>, R<5>, R<6>, R<7> and R<8> are each, independently, hydrogen, acyl of 1 to 6 carbon atoms, benzyl substituted with R<1>, and R<2>; or benzoyl substituted with R<1> and R<2>; R<9> and R<10> are each, independently, acyl of 1 to 6 carbon atoms, or the R<9> and R<10> groups on the 4' and 6' positions of the maltose may be taken together to form a cyclic acetal which may be substituted with alkyl of 1 to 6 carbon atoms, two alkyl groups each having 1 to 6 carbon atoms, pyridine substituted with R<1>, phenyl substituted with R<1>, benzyl substituted with R<1>, 2-phenylethyl substituted with R<1>, or 3-phenylpropyl substituted with R<1>; or a pharmaceutically acceptable salt thereof.
IPC 1-7
C07H 13/04; A61K 31/70; A61P 9/00; A61P 21/00; A61P 35/00; C07H 13/08; C07H 13/10
IPC 8 full level
C07H 13/04 (2006.01); A61K 31/7024 (2006.01); A61K 31/706 (2006.01); A61P 9/04 (2006.01); A61P 9/08 (2006.01); A61P 9/12 (2006.01); A61P 9/14 (2006.01); A61P 11/06 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07H 15/18 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 9/04 (2017.12); A61P 9/08 (2017.12); A61P 9/12 (2017.12); A61P 9/14 (2017.12); A61P 11/06 (2017.12); A61P 21/00 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07H 15/18 (2013.01)
Citation (search report)
See references of WO 0031093A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0031093 A2 20000602; WO 0031093 A3 20001228; AU 1743700 A 20000613; BR 9915612 A 20010814; CA 2350758 A1 20000602; CN 1333781 A 20020130; EP 1133508 A2 20010919; JP 2002530418 A 20020917
DOCDB simple family (application)
US 9927780 W 19991123; AU 1743700 A 19991123; BR 9915612 A 19991123; CA 2350758 A 19991123; CN 99815709 A 19991123; EP 99960570 A 19991123; JP 2000583921 A 19991123