EP 1135144 A1 20010926 - COMPOSITIONS AND METHODS FOR REGULATING BACTERIAL PATHOGENESIS
Title (en)
COMPOSITIONS AND METHODS FOR REGULATING BACTERIAL PATHOGENESIS
Title (de)
ZUSAMMENSETZUNGEN UND METHODEN ZUR REGULATION DER BAKTERIELLEN PATHOGENESE
Title (fr)
COMPOSITIONS ET METHODES DE REGULATION DE LA PATHOGENESE BACTERIENNE
Publication
Application
Priority
- US 9928751 W 19991202
- US 11057098 P 19981202
Abstract (en)
[origin: WO0032152A2] This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
IPC 1-7
A61K 39/106; C12N 5/00; C12N 5/02; G01N 33/53; G01N 33/566; G01N 33/569
IPC 8 full level
G01N 33/50 (2006.01); A61K 31/00 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 31/04 (2006.01); A61P 43/00 (2006.01); C07C 49/17 (2006.01); C07K 14/00 (2006.01); C07K 14/28 (2006.01); C12N 1/20 (2006.01); C12N 5/02 (2006.01); C12N 15/09 (2006.01); C12P 7/26 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 21/76 (2006.01); G01N 21/77 (2006.01); G01N 21/78 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01); C12R 1/63 (2006.01)
CPC (source: EP KR)
A61K 31/00 (2013.01 - EP); A61K 31/121 (2013.01 - KR); A61P 31/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); Y02A 50/30 (2017.12 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0032152 A2 20000608; WO 0032152 A3 20021212; AU 1933800 A 20000619; CA 2351731 A1 20000608; EP 1135144 A1 20010926; EP 1135144 A4 20050720; JP 2003526327 A 20030909; KR 20010093800 A 20011029
DOCDB simple family (application)
US 9928751 W 19991202; AU 1933800 A 19991202; CA 2351731 A 19991202; EP 99963011 A 19991202; JP 2000584850 A 19991202; KR 20017006954 A 20010602