EP 1135382 A1 20010926 - METHOD OF PRODUCING PAROXETINE HYDROCHLORIDE
Title (en)
METHOD OF PRODUCING PAROXETINE HYDROCHLORIDE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON PAROXETIN HYDROCHLORID
Title (fr)
PROCEDE DE FABRICATION D'HYDROCHLORURE DE PAROXETINE
Publication
Application
Priority
- GB 9903992 W 19991130
- GB 9826180 A 19981130
Abstract (en)
[origin: WO0032593A1] The present invention relates to a new process for preparing pharmaceutically active compounds and intermediates therefor. The (-) trans isomer of 4-(4'-fluorophenyl)-3-(3",4"-methylenedioxyphenoxymethyl)piperidine (paroxetine) is an important compound having antidepressant and anti-Parkinson properties. This compound is used in therapy as the hydrochloride salt to treat inter alia depression, obsessive compulsive disorder (OCD) and panic. There is described herein an improved process for its preparation which avoids the generation of impurities caused by the use of strong mineral acid to form the salt.
IPC 1-7
IPC 8 full level
A61K 31/443 (2006.01); A61K 31/4525 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 15/00 (2006.01); A61P 17/14 (2006.01); A61P 25/04 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/32 (2006.01); A61P 29/00 (2006.01); C07D 405/12 (2006.01)
CPC (source: EP)
A61P 3/04 (2017.12); A61P 3/10 (2017.12); A61P 15/00 (2017.12); A61P 17/14 (2017.12); A61P 25/04 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 25/32 (2017.12); A61P 29/00 (2017.12); C07D 405/12 (2013.01)
Citation (search report)
See references of WO 0032593A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0032593 A1 20000608; AU 1397800 A 20000619; EP 1135382 A1 20010926; GB 9826180 D0 19990120; JP 2002531451 A 20020924
DOCDB simple family (application)
GB 9903992 W 19991130; AU 1397800 A 19991130; EP 99973026 A 19991130; GB 9826180 A 19981130; JP 2000585235 A 19991130