EP 1137340 A1 20011004 - COMPOSITION AND METHOD FOR REGULATION OF BODY WEIGHT AND ASSOCIATED CONDITIONS
Title (en)
COMPOSITION AND METHOD FOR REGULATION OF BODY WEIGHT AND ASSOCIATED CONDITIONS
Title (de)
ZUSAMMENSETZUNG UND VERFAHREN ZUR REGULATION DES KÖRPERGEWICHTES UND DAMIT ZUSAMMENHÄNGENDER ZUSTÄNDE
Title (fr)
COMPOSITION ET PROCEDES DE REGULATION DU POIDS CORPOREL ET DES PATHOLOGIES ASSOCIEES
Publication
Application
Priority
- US 9929337 W 19991209
- US 11158198 P 19981209
- US 14630699 P 19990729
- US 14630599 P 19990729
- US 14630499 P 19990729
- US 14630399 P 19990729
- US 14630299 P 19990729
- US 14630199 P 19990729
- US 14630099 P 19990729
- US 14629999 P 19990729
- US 37482799 A 19990812
Abstract (en)
[origin: WO0033658A1] Described are methods and compositions for regulating body weight and/or regulating the rate of weight gain or loss, and particularly, for treating or preventing obesity. Specifically, methods of administering varying levels of circulating proopiomelanocortin peptides or analogs thereof to an animal, alone or in combination with leptin or other body weight regulating agents are disclosed. Methods and compositions for treating a variety of disorders associated with or caused by undesirable body weight are also described. Also described are methods for identifying compounds useful for regulation of body weight and associated conditions. In particular, methods are disclosed for identification of compounds that preferentially bind to and/or activate peripheral melanocortin receptors and which minimize binding and/or activation of central melanocortin receptors. Also described is a genetically modified non-human animal model for studying the peripheral and central pathways of energy homeostasis. Also disclosed are methods of identifying compounds for regulating such pathways and a POMC mutant mouse.
IPC 1-7
G01N 33/00; A01K 67/027; A61K 38/03; A61P 3/04; A61P 25/00; A61P 43/00
IPC 8 full level
A01K 67/00 (2006.01); A61K 38/03 (2006.01); C07K 14/665 (2006.01); C07K 14/705 (2006.01); G01N 33/00 (2006.01)
CPC (source: EP)
A61P 3/04 (2017.12); A61P 25/00 (2017.12); A61P 43/00 (2017.12); C07K 14/665 (2013.01); C07K 14/705 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0033658 A1 20000615; AU 3117600 A 20000626; CA 2353776 A1 20000615; EP 1137340 A1 20011004; EP 1137340 A4 20051221; JP 2003520015 A 20030702; MX PA01005818 A 20030721
DOCDB simple family (application)
US 9929337 W 19991209; AU 3117600 A 19991209; CA 2353776 A 19991209; EP 99965208 A 19991209; JP 2000586172 A 19991209; MX PA01005818 A 19991209