Global Patent Index - EP 1137412 A4

EP 1137412 A4 20020403 - SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF

Title (en)

SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF

Title (de)

SUBSTITUIERTE STICKSTOFFHALTIGE HETEROCYCLISCHE VERBINDUNGEN UND DEREN THERAPEUTISCHE VERWENDUNG

Title (fr)

COMPOSES HETEROCYCLIQUES AZOTES SUBSTITUES ET LEUR UTILISATION THERAPEUTIQUE

Publication

EP 1137412 A4 20020403 (EN)

Application

EP 99965946 A 19991201

Priority

  • US 9928374 W 19991201
  • US 11183998 P 19981211

Abstract (en)

[origin: WO0033788A2] This invention relates to substituted nitrogen heterocyclic compounds having general formulas (1) and (2). This invention further relates to pharmaceutical compositions comprising these compounds, and therapeutic uses of such compositions for treating or controlling the symptoms of memory loss, Alzheimer's disease, senile dementia or similar conditions.

IPC 1-7

A61K 31/40; A61K 31/445; C07D 207/16; C07D 207/08; C07D 207/09; C07D 211/22; C07D 211/26; C07D 211/60; C07D 223/12; A61K 31/55; A61P 25/28

IPC 8 full level

C07D 207/09 (2006.01); C07D 207/16 (2006.01); C07D 211/26 (2006.01); C07D 211/60 (2006.01); C07D 223/12 (2006.01)

CPC (source: EP)

A61P 25/28 (2017.12); C07D 207/09 (2013.01); C07D 207/16 (2013.01); C07D 211/26 (2013.01); C07D 211/60 (2013.01); C07D 223/12 (2013.01)

Citation (search report)

  • [X] EP 0296560 A2 19881228 - EISAI CO LTD [JP]
  • [X] US 5053548 A 19911001 - TANAKA TATSUYOSHI [JP], et al
  • [X] US 5446147 A 19950829 - KUNG HANK F [US], et al
  • [X] GB 1508880 A 19780426 - SYNTHELABO
  • [PX] ZHAO S ET AL: "SYNTHESES OF 1,2-DIAMINO AND 1,2-AMINOALCOHOL DERIVATIVES IN THE PIPERIDINE AND PYRROLDINE SERIES AS ANTI-AMNESIC AGENTS", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 7, 1999, pages 1647 - 1654, XP002928878, ISSN: 0968-0896
  • [X] PATENT ABSTRACTS OF JAPAN vol. 014, no. 310 (C - 0736) 4 July 1990 (1990-07-04)
  • [X] COREY, E. J.; LINK, J. O.: "A Catalytic Enantioselective Synthesis of Denopamine, a Useful Drug for Congestive Heart Failure", J. ORG. CHEM, vol. 56, no. 1, 1991, pages 442 - 444, XP001055628
  • [X] CHANDRAKUMAR, N. S. ET AL.: "Preparation and Opioid Activity of Analogues of the Analgesic Dipeptide 2,6-Dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide", J. MED. CHEM., vol. 35, no. 2, 1992, pages 223 - 233, XP001026297
  • [X] O'NEIL I A ET AL: "The Highly Stereoselective Formation of Pipecolic Acid N-Oxide and Related Derivatives", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 38, no. 32, 1 August 1997 (1997-08-01), pages 5731 - 5734, XP004085745, ISSN: 0040-4039
  • [X] BARLOCCO, D. ET AL: "Monocyclic Analogues of the m-Opioid Antagonist 3,8-Diazabicyclo-[3.2.1]octanes: Synthesis Modeling and Activities", TETRAHEDRON, vol. 51, no. 42, 1995, pages 11547 - 11556, XP001026295
  • [X] MORIE, T. ET AL: "Ring Expansion of Nitrogen-containing Chloromethylheteroalicycles via Aziridinium Intermediates", J. CHEM. SOC. PERKIN TRANS. I, vol. 18, 1994, pages 2565 - 2570, XP001055909
  • [X] DEHMLOW, E. V. ET AL: "Revisiting optically active quaternary derivatives made from prolinol as phase transfer catalysts", TETRAHEDRON ASYMMETRY, vol. 9, no. 13, 1998, pages 2235 - 2244, XP004131368
  • See references of WO 0033788A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0033788 A2 20000615; WO 0033788 A3 20001019; AU 2160900 A 20000626; CA 2355296 A1 20000615; EP 1137412 A2 20011004; EP 1137412 A4 20020403

DOCDB simple family (application)

US 9928374 W 19991201; AU 2160900 A 19991201; CA 2355296 A 19991201; EP 99965946 A 19991201