EP 1137659 A4 20050810 - INHIBITION OF ANGIOGENESIS BY HIGH MOLECULAR WEIGHT KININOGEN AND PEPTIDE ANALOGS THEREOF
Title (en)
INHIBITION OF ANGIOGENESIS BY HIGH MOLECULAR WEIGHT KININOGEN AND PEPTIDE ANALOGS THEREOF
Title (de)
HEMMUNG VON ANGIOGENESE DURCH HOCHMOLEKULARES KININOGEN UND PEPTIDANALOGA DAVON
Title (fr)
INHIBITION DE L'ANGIOGENESE PAR DU KININOGENE DE POIDS MOLECULAIRE ELEVE ET ANALOGUES PEPTIDIQUES DUDIT KININOGENE
Publication
Application
Priority
- US 9926419 W 19991105
- US 10783398 P 19981110
Abstract (en)
[origin: WO0027866A1] Two-chain high molecular weight kininogen, and peptide analogs thereof having homology to sites within kininogen domain 5, are potent inhibitors of angiogenesis. The peptides have the formula X1-His-Lys-X-Lys-X2 wherein X is any amino acid, X1 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids, and X2 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids. X is preferably an amino acid having a nonpolar side chain, or a polar side chain which is uncharged at pH 6.0 to 7.0. X is most preferably Asn, Phe or His. Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.
IPC 1-7
C07H 21/04; A61K 31/47; G01N 33/53; C07K 7/00; C12Q 1/68; C07K 14/745; C07K 5/10; A61K 38/07; A61K 38/08; A61K 38/36; C07K 7/08; C07K 14/47
IPC 8 full level
C12N 5/07 (2010.01); A61K 38/00 (2006.01); A61K 38/48 (2006.01); A61P 9/00 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/81 (2006.01); C12N 5/071 (2010.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 27/02 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 7/08 (2013.01); C07K 14/8139 (2013.01); A61K 38/00 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
- No further relevant documents disclosed
- See references of WO 0027866A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0027866 A1 20000518; AU 1910600 A 20000529; AU 773862 B2 20040610; CA 2350915 A1 20000518; EP 1137659 A1 20011004; EP 1137659 A4 20050810; IL 142822 A0 20020310; JP 2002529474 A 20020910; NZ 511618 A 20030630; ZA 200104130 B 20020521
DOCDB simple family (application)
US 9926419 W 19991105; AU 1910600 A 19991105; CA 2350915 A 19991105; EP 99962723 A 19991105; IL 14282299 A 19991105; JP 2000581043 A 19991105; NZ 51161899 A 19991105; ZA 200104130 A 20010521