EP 1137774 A2 20011004 - GRNF4, A GDNF-RELATED NEUROTROPHIC FACTOR
Title (en)
GRNF4, A GDNF-RELATED NEUROTROPHIC FACTOR
Title (de)
GRNF4, EIN GDNF-ÄHNLICHER NEUROTROPHER FAKTOR
Title (fr)
FACTEUR DE CROISSANCE NEUROTROPHIQUE ISSU DES CELLULES GLIALES (GRNF4), UN FACTEUR NEUROTROPHIQUE
Publication
Application
Priority
- US 9928975 W 19991208
- US 11162698 P 19981209
Abstract (en)
[origin: WO0034475A2] The present invention relates to novel molecules referred to as GDNF-related neurotrophic factor 4 (GRNF4). The present invention involves the cloning, expression, characterization and use of GRNF4. Polynucleotide molecules and amino acid sequences are described for GRNF4. GRNF4 is 35 % identical to glial cell line-derived neurotrophic factor and 46 % identical to neurturin. GRNF4 binds to GFR alpha -3 which is a receptor of the GFR alpha family exclusively expressed in the peripheral sensory and sympathetic nervous systems.
[origin: WO0034475A2] The present invention relates to molecules referred to as GDNF-related neurotrophic factor 4 (GRNF4). The present invention involves the cloning, expression, characterization and use of GRNF4. Polynucleotide molecules and amino acid sequences are described for GRNF4. GRNF4 is 35 % identical to glial cell line-derived neurotrophic factor and 46 % identical to neurturin. GRNF4 binds to GFR alpha -3 which is a receptor of the GFR alpha family exclusively expressed in the peripheral sensory and sympathetic nervous systems.
IPC 1-7
C12N 15/12; C07K 14/475; C07K 16/22; C12N 5/10; C12N 5/12; A61K 38/18; A61K 35/12
IPC 8 full level
A61K 38/00 (2006.01); A61P 3/14 (2006.01); A61P 19/10 (2006.01); A61P 25/02 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07K 14/475 (2006.01); C07K 14/48 (2006.01); C07K 16/22 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP)
A61P 3/14 (2017.12); A61P 19/10 (2017.12); A61P 25/02 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); C07K 14/475 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 0034475A2
Citation (third parties)
Third party :
WO 0018799 A1 20000406 - UNIV WASHINGTON [US], et al
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0034475 A2 20000615; WO 0034475 A3 20001109; WO 0034475 A9 20020829; AU 2354600 A 20000626; EP 1137774 A2 20011004; JP 2002531128 A 20020924
DOCDB simple family (application)
US 9928975 W 19991208; AU 2354600 A 19991208; EP 99967225 A 19991208; JP 2000586909 A 19991208