EP 1137940 A4 20040602 - ASSAYS FOR LIGANDS FOR NUCLEAR RECEPTORS
Title (en)
ASSAYS FOR LIGANDS FOR NUCLEAR RECEPTORS
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG VON LIGANDEN VON NUKLEÄREN REZEPTOREN
Title (fr)
PROCEDE D'IDENTIFICATION DE LIGANDS DE RECEPTEURS NUCLEAIRES
Publication
Application
Priority
- US 9924956 W 19991022
- US 10539098 P 19981023
- US 13509798 P 19981223
- US 13483699 P 19990519
Abstract (en)
[origin: WO0025134A1] The present invention includes new nuclear receptor heterodimer and nuclear receptor-coactivator peptide assays for identifying ligands for nuclear receptors, utilizing scintillation proximity and fluorescence resonance energy transfer (FRET).
IPC 1-7
IPC 8 full level
C07K 14/00 (2006.01); C07K 14/705 (2006.01); G01N 33/533 (2006.01); G01N 33/534 (2006.01); G01N 33/542 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
G01N 33/542 (2013.01); G01N 33/566 (2013.01); G01N 33/6875 (2013.01)
Citation (search report)
- [PXPY] WO 9950664 A1 19991007 - GLAXO GROUP LTD [GB], et al
- [PXPY] WO 9918124 A1 19990415 - MERCK & CO INC [US], et al
- [X] WO 9832444 A1 19980730 - UNIV CALIFORNIA [US], et al
- [X] WO 9621742 A1 19960718 - SALK INST FOR BIOLOGICAL STUDI [US]
- [DXY] ZHOU G ET AL: "NUCLEAR RECEPTORS HAVE DISTINCT AFFINITIES FOR COACTIVATORS: CHARACTERIZATION BY FLUORESCENCE RESONANCE ENERGY TRANSFER", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 12, no. 10, October 1998 (1998-10-01), pages 1594 - 1604, XP002934409, ISSN: 0888-8809
- [YD] KREY G ET AL: "FATTY ACIDS, EICOSANOIDS, AND HYPOLIPIDEMIC AGENTS IDENTIFIED AS LIGANDS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS BY COACTIVATOR-DEPENDENT RECEPTOR LIGAND ASSAY", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 11, no. 6, June 1997 (1997-06-01), pages 779 - 791, XP002915086, ISSN: 0888-8809
- [Y] NICHOLS JAMES S ET AL: "Development of a scintillation proximity assay for peroxisome proliferator-activated receptor gamma ligand binding domain.", ANALYTICAL BIOCHEMISTRY, vol. 257, no. 2, 15 March 1998 (1998-03-15), pages 112 - 119, XP002214931, ISSN: 0003-2697
- [Y] NOLTE R T ET AL: "LIGAND BINDING AND CO-ACTIVATOR ASSEMBLY OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 395, 10 September 1998 (1998-09-10), pages 137 - 143, XP002906503, ISSN: 0028-0836
- [PXY] PARKS DEREK J ET AL: "Bile acids: Natural ligands for an orphan nuclear receptor.", SCIENCE (WASHINGTON D C), vol. 284, no. 5418, 21 May 1999 (1999-05-21), pages 1365 - 1368, XP000892009, ISSN: 0036-8075
- [XP] NIESOR ERIC J ET AL: "Synthetic farnesoid X receptor (FXR) agonists: A new class of cholesterol synthesis inhibitors and antiproliferative drugs", DRUGS OF THE FUTURE, vol. 24, no. 4, April 1999 (1999-04-01), &, pages 431 - 438, XP009028203, ISSN: 0377-8282
- [XY] DONG DIANE ET AL: "Heterodimer formation by retinoid X receptor: Regulation by ligands and by the receptor's self-association properties", BIOCHEMISTRY, vol. 37, no. 30, 28 July 1998 (1998-07-28), &, pages 10691 - 10700, XP001180506, ISSN: 0006-2960
- [XY] HAUSSLER M R ET AL: "THE VITAMIN D HORMONE AND ITS NUCLEAR RECEPTOR: MOLECULAR ACTIONS AND DISEASE STATES", JOURNAL OF ENDOCRINOLOGY, BRISTOL, GB, vol. 154, September 1997 (1997-09-01), pages S57 - S73, XP000867746, ISSN: 0022-0795
- [A] MINUCCI SAVERIO ET AL: "Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 2, 1997, &, pages 644 - 655, XP002274485, ISSN: 0270-7306
- See references of WO 0025134A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0025134 A1 20000504; AU 1229000 A 20000515; EP 1137940 A1 20011004; EP 1137940 A4 20040602; JP 2002528721 A 20020903
DOCDB simple family (application)
US 9924956 W 19991022; AU 1229000 A 19991022; EP 99971090 A 19991022; JP 2000578657 A 19991022